National Centre for Epidemiology, Carlos III Institute of Health, and Consortium for Biomedical Research in Neurodegenerative Diseases (CIBERNED), Av Monforte de Lemos 5, Madrid 28029, Spain.
BMC Neurol. 2013 Jun 12;13:58. doi: 10.1186/1471-2377-13-58.
A debate surrounding multiple sclerosis epidemiology has centred on time-related incidence increases and the need of monitoring. The purpose of this study is to reassess multiple sclerosis incidence in the European Economic Area.
We conducted a systematic review of literature from 1965 onwards and integrated elements of original research, including requested or completed data by surveys authors and specific analyses.
The review of 5323 documents yielded ten studies for age- and sex-specific analyses, and 21 studies for time-trend analysis of single data sets. After 1985, the incidence of multiple sclerosis ranged from 1.12 to 6.96 per 100,000 population, was higher in females, tripled with latitude, and doubled with study midpoint year. The north registered increasing trends from the 1960s and 1970s, with a historic drop in the Faroe Islands, and fairly stable data in the period 1980-2000; incidence rose in Italian and French populations in the period 1970-2000, in Evros (Greece) in the 1980s, and in the French West Indies in around 2000.
We conclude that the increase in multiple sclerosis incidence is only apparent, and that it is not specific to women. Monitoring of multiple sclerosis incidence might be appropriate for the European Economic Area.
围绕多发性硬化症流行病学的争论集中在与时间相关的发病率增加和监测需求上。本研究旨在重新评估欧洲经济区多发性硬化症的发病率。
我们对 1965 年以后的文献进行了系统回顾，并整合了原始研究的要素，包括作者要求或完成的调查数据以及特定的分析。
对 5323 份文件的审查得出了 10 项年龄和性别特定分析研究，以及 21 项关于单个数据集时间趋势分析的研究。1985 年后，多发性硬化症的发病率范围为每 10 万人 1.12 至 6.96 例，女性发病率更高，随纬度增加三倍，随研究中点年份增加一倍。北部从 20 世纪 60 年代和 70 年代开始呈上升趋势，法罗群岛的历史发病率下降，1980-2000 年期间数据较为稳定；1970-2000 年间，意大利和法国的发病率上升，1980 年代在埃夫罗斯（希腊）上升，2000 年左右在法属西印度群岛上升。
我们得出的结论是，多发性硬化症发病率的增加只是表面现象，而且并非女性特有。对多发性硬化症发病率的监测可能适合欧洲经济区。
