Alonso-Magdalena Lucía, Zia Elisabet, Carmona I Codina Olga, Pessah-Rasmussen Hélène, Sundström Peter
Department of Neurology, Skåne University Hospital and Department of Clinical Sciences, Lund University, Lund, Sweden.
Department of Clinical Sciences, Lund University, Malmö, Sweden.
Mult Scler Int. 2022 Mar 19;2022:5464370. doi: 10.1155/2022/5464370. eCollection 2022.
To estimate the incidence and prevalence of multiple sclerosis (MS) in Malmö municipality in southwestern Sweden.
Multiple sources were used in the case identification process. Case ascertainment was assessed by medical chart review including examinations such as magnetic resonance imaging, cerebrospinal fluid analyses, and relevant laboratory tests. Cases were classified according to the 2010 McDonald's diagnostic criteria. Onset-adjusted prevalence and a definition of onset symptoms were applied.
The crude incidence of MS in 2001-2010 in Malmö municipality was 5.3/100,000 (95% confidence interval (CI): 4.5 to 6.2). There was a relapsing onset in 90.5% of cases. The female to male ratio was 1.8. The onset-adjusted prevalence for Dec 2010 was 133/100,000 (95% CI, 120 to 146) with a female to male ratio of 2.1.
This is the first population-based epidemiological study in Skåne, the most southwestern part of Sweden showing a high incidence and prevalence. We found a lower incidence than expected according to previous nationwide figures, probably due to methodological differences between the studies. Our findings support the presence of a north-south gradient of MS prevalence in Sweden.
评估瑞典西南部马尔默市多发性硬化症（MS）的发病率和患病率。
病例识别过程中使用了多种来源。通过病历审查评估病例确诊情况，包括磁共振成像、脑脊液分析及相关实验室检查等。病例根据2010年麦克唐纳诊断标准进行分类。应用发病调整患病率及发病症状定义。
2001 - 2010年马尔默市MS的粗发病率为5.3/10万（95%置信区间（CI）：4.5至6.2）。90.5%的病例起病为复发型。女性与男性比例为1.8。2010年12月的发病调整患病率为133/10万（95%CI，120至146），女性与男性比例为2.1。
这是瑞典最西南部斯科讷地区第一项基于人群的流行病学研究，显示出较高的发病率和患病率。我们发现发病率低于根据之前全国数据预期的水平，可能是由于研究方法的差异。我们的研究结果支持瑞典MS患病率存在南北梯度差异。
