• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Current status of ketamine and related compounds for depression.

作者信息

Mathews Daniel C, Zarate Carlos A

机构信息

Experimental Therapeutics and Pathophysiology Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, and Department of Health and Human Services, Bethesda, MD, USA.

出版信息

J Clin Psychiatry. 2013 May;74(5):516-7. doi: 10.4088/JCP.13ac08382.

DOI:10.4088/JCP.13ac08382
PMID:23759454
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3785314/
Abstract
摘要

相似文献

1
Current status of ketamine and related compounds for depression.氯胺酮及相关化合物治疗抑郁症的现状
J Clin Psychiatry. 2013 May;74(5):516-7. doi: 10.4088/JCP.13ac08382.
2
Ketamine as an alternative treatment for treatment-resistant depression.氯胺酮作为难治性抑郁症的一种替代治疗方法。
Perspect Psychiatr Care. 2013 Jan;49(1):2-4. doi: 10.1111/ppc.12006. Epub 2012 Dec 30.
3
Safety and Tolerability of Ketamine Use in Treatment-Resistant Bipolar Depression Patients with Regard to Central Nervous System Symptomatology: Literature Review and Analysis.治疗抵抗性双相情感障碍患者使用氯胺酮的安全性和耐受性与中枢神经系统症状相关：文献综述与分析。
Medicina (Kaunas). 2020 Feb 9;56(2):67. doi: 10.3390/medicina56020067.
4
Research suggests new drug targets for depression. Pilot studies of ketamine intrigue scientists, but risks of this anesthetic limit its clinical use.研究表明了治疗抑郁症的新药物靶点。氯胺酮的初步研究引起了科学家们的兴趣，但这种麻醉剂的风险限制了其临床应用。
Harv Ment Health Lett. 2010 Nov;27(5):6.
5
Subanesthetic ketamine infusions for suicide ideation in patients with bipolar and unipolar treatment refractory depression.亚麻醉剂量氯胺酮输注用于双相和单相治疗难治性抑郁症患者的自杀观念。
Psychiatry Res. 2021 Feb;296:113645. doi: 10.1016/j.psychres.2020.113645. Epub 2020 Dec 16.
6
Ketamine's effectiveness in unipolar versus bipolar depression.氯胺酮在单相抑郁与双相抑郁中的疗效。
Psychopharmacology (Berl). 2014 Nov;231(22):4417-8. doi: 10.1007/s00213-014-3773-1. Epub 2014 Oct 15.
7
The effectiveness of ketamine on anxiety, irritability, and agitation: Implications for treating mixed features in adults with major depressive or bipolar disorder.氯胺酮对焦虑、烦躁和激越的疗效：对治疗成人重性抑郁或双相障碍混合特征的意义。
Bipolar Disord. 2020 Dec;22(8):831-840. doi: 10.1111/bdi.12941. Epub 2020 Jul 8.
8
The Concurrent Treatment With Intravenous Ketamine and an Irreversible Monoamine Oxidase Inhibitor for Treatment-Resistant Depression Without Hypertensive Crises.静脉注射氯胺酮与不可逆单胺氧化酶抑制剂联合治疗难治性抑郁症且无高血压危象。
J Clin Psychopharmacol. 2020 Sep/Oct;40(5):515-517. doi: 10.1097/JCP.0000000000001244.
9
Ketamine administration in depressive disorders: a systematic review and meta-analysis.氯胺酮在抑郁症治疗中的应用：一项系统综述和荟萃分析。
Psychopharmacology (Berl). 2014 Sep;231(18):3663-76. doi: 10.1007/s00213-014-3664-5. Epub 2014 Jul 20.
10
KETAMINE FOR TREATMENT-RESISTANT UNIPOLAR AND BIPOLAR MAJOR DEPRESSION: CRITICAL REVIEW AND IMPLICATIONS FOR CLINICAL PRACTICE.氯胺酮用于难治性单相和双相重度抑郁症：批判性综述及对临床实践的启示
Depress Anxiety. 2016 Aug;33(8):698-710. doi: 10.1002/da.22505. Epub 2016 Apr 6.

引用本文的文献

1
Combined Fluoxetine and Metformin Treatment Potentiates Antidepressant Efficacy Increasing IGF2 Expression in the Dorsal Hippocampus.联合氟西汀和二甲双胍治疗可增强抗抑郁疗效，增加海马背侧 IGF2 的表达。
Neural Plast. 2019 Jan 21;2019:4651031. doi: 10.1155/2019/4651031. eCollection 2019.
2
Cognitive and Neurophysiological Recovery Following Electroconvulsive Therapy: A Study Protocol.电休克治疗后的认知与神经生理恢复：一项研究方案
Front Psychiatry. 2018 May 14;9:171. doi: 10.3389/fpsyt.2018.00171. eCollection 2018.
3
A Circadian Genomic Signature Common to Ketamine and Sleep Deprivation in the Anterior Cingulate Cortex.生物钟基因组特征在安前扣带皮层中与氯胺酮和睡眠剥夺共同存在。
Biol Psychiatry. 2017 Sep 1;82(5):351-360. doi: 10.1016/j.biopsych.2017.02.1176. Epub 2017 Mar 1.
4
Rapid Resolution of Grief with IV Infusion of Ketamine: A Unique Phenomenological Experience.静脉输注氯胺酮快速缓解悲伤：一种独特的现象学体验。
Indian J Psychol Med. 2016 Jan-Feb;38(1):62-4. doi: 10.4103/0253-7176.175121.
5
Ketamine infusion for patients receiving extracorporeal membrane oxygenation support: a case series.接受体外膜肺氧合支持的患者静脉输注氯胺酮：病例系列
F1000Res. 2015 Jan 16;4:16. doi: 10.12688/f1000research.6006.1. eCollection 2015.
6
Pharmacological approaches to the challenge of treatment-resistant depression.应对难治性抑郁症挑战的药理学方法。
Dialogues Clin Neurosci. 2015 Jun;17(2):111-26. doi: 10.31887/DCNS.2015.17.2/dionescu.
7
Distinct Neuropsychological Mechanisms May Explain Delayed- Versus Rapid-Onset Antidepressant Efficacy.不同的神经心理学机制可能解释延迟起效与快速起效抗抑郁药的疗效差异。
Neuropsychopharmacology. 2015 Aug;40(9):2165-74. doi: 10.1038/npp.2015.59. Epub 2015 Mar 5.
8
Circadian dysregulation of clock genes: clues to rapid treatments in major depressive disorder.生物钟基因的昼夜节律失调：重度抑郁症快速治疗的线索
Mol Psychiatry. 2015 Feb;20(1):48-55. doi: 10.1038/mp.2014.138. Epub 2014 Nov 4.
9
Inflammation: a mechanism of depression?炎症：抑郁的一种机制？
Neurosci Bull. 2014 Jun;30(3):515-23. doi: 10.1007/s12264-013-1439-3. Epub 2014 May 16.
10
Stress and VTA synapses: implications for addiction and depression.应激与腹侧被盖区突触：对成瘾和抑郁的影响
Eur J Neurosci. 2014 Apr;39(7):1179-88. doi: 10.1111/ejn.12490.

本文引用的文献

1
Synaptic mechanisms underlying rapid antidepressant action of ketamine.氯胺酮快速抗抑郁作用的突触机制。
Am J Psychiatry. 2012 Nov;169(11):1150-6. doi: 10.1176/appi.ajp.2012.12040531.
2
A randomized trial of a low-trapping nonselective N-methyl-D-aspartate channel blocker in major depression.一项针对重度抑郁症的低捕获非选择性 N-甲基-D-天冬氨酸通道阻滞剂的随机试验。
Biol Psychiatry. 2013 Aug 15;74(4):257-64. doi: 10.1016/j.biopsych.2012.10.019. Epub 2012 Dec 1.
3
A 12-month naturalistic observation of three patients receiving repeat intravenous ketamine infusions for their treatment-resistant depression.对 3 名接受重复静脉注射氯胺酮治疗难治性抑郁症的患者进行了为期 12 个月的自然观察。
J Affect Disord. 2013 May;147(1-3):416-20. doi: 10.1016/j.jad.2012.10.015. Epub 2012 Nov 22.
4
Rapid and longer-term antidepressant effects of repeated ketamine infusions in treatment-resistant major depression.重复氯胺酮输注治疗难治性重度抑郁症的快速和长期抗抑郁作用。
Biol Psychiatry. 2013 Aug 15;74(4):250-6. doi: 10.1016/j.biopsych.2012.06.022. Epub 2012 Jul 27.
5
A neurotrophic hypothesis of depression: role of synaptogenesis in the actions of NMDA receptor antagonists.抑郁的神经营养假说：NMDA 受体拮抗剂作用中的突触发生作用。
Philos Trans R Soc Lond B Biol Sci. 2012 Sep 5;367(1601):2475-84. doi: 10.1098/rstb.2011.0357.
6
Effects of ketamine in treatment-refractory obsessive-compulsive disorder.氯胺酮治疗难治性强迫症的效果。
Biol Psychiatry. 2012 Dec 1;72(11):964-70. doi: 10.1016/j.biopsych.2012.05.028. Epub 2012 Jul 10.
7
Targeting the glutamatergic system to treat major depressive disorder: rationale and progress to date.针对谷氨酸能系统治疗重度抑郁症：基本原理和迄今为止的进展。
Drugs. 2012 Jul 9;72(10):1313-33. doi: 10.2165/11633130-000000000-00000.
8
A Randomized, placebo-controlled, crossover pilot trial of the oral selective NR2B antagonist MK-0657 in patients with treatment-resistant major depressive disorder.一项口服选择性 NR2B 拮抗剂 MK-0657 治疗难治性重度抑郁症患者的随机、安慰剂对照、交叉先导试验。
J Clin Psychopharmacol. 2012 Aug;32(4):551-7. doi: 10.1097/JCP.0b013e31825d70d6.
9
Ketamine-associated urinary tract dysfunction: an underrecognized clinical entity.氯胺酮相关的泌尿道功能障碍：一种未被充分认识的临床实体。
Urol Int. 2012;89(1):93-6. doi: 10.1159/000338098. Epub 2012 Jun 16.
10
Ketamine for depression: where do we go from here?氯胺酮治疗抑郁症：我们的路在何方？
Biol Psychiatry. 2012 Oct 1;72(7):537-47. doi: 10.1016/j.biopsych.2012.05.003. Epub 2012 Jun 16.