Polter Abigail M, Kauer Julie A
Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, Providence, RI, 02912, USA.
Eur J Neurosci. 2014 Apr;39(7):1179-88. doi: 10.1111/ejn.12490.
While stressful experiences are a part of everyone's life, they can also exact a major toll on health. Stressful life experiences are associated with increased substance abuse, and there exists significant co-morbidity between mental illness and substance use disorders [N.D. Volkow & T.K. Li (2004) Nat. Rev. Neurosci., 5, 963-970; G. Koob & M.J. Kreek (2007) Am. J. Psych., 164, 1149-1159; R. Sinha (2008) Annals N.Y. Acad. Sci., 1141, 105-130]. The risk for development of mood or anxiety disorders after stress is positively associated with the risk for substance use disorders [R. Sinha (2008) Annals N.Y. Acad. Sci., 1141, 105-130], suggesting that there are common substrates for vulnerability to addictive and affective disorders. Understanding the molecular and physiological substrates of stress may lead to improved therapeutic interventions for the treatment of substance use disorders and mental illnesses.
虽然压力体验是每个人生活的一部分，但它们也会对健康造成重大损害。有压力的生活经历与药物滥用增加有关，并且精神疾病和物质使用障碍之间存在显著的共病现象 [N.D. 沃尔科夫 & T.K. 李 (2004) 《自然评论：神经科学》，5, 963 - 970；G. 库布 & M.J. 克里克 (2007) 《美国精神病学杂志》，164, 1149 - 1159；R. 辛哈 (2008) 《纽约科学院学报》，1141, 105 - 130]。压力后出现情绪或焦虑障碍的风险与物质使用障碍的风险呈正相关 [R. 辛哈 (2008) 《纽约科学院学报》，1141, 105 - 130]，这表明存在易患成瘾性和情感性障碍的共同基础。了解压力的分子和生理基础可能会带来针对物质使用障碍和精神疾病治疗的改进治疗干预措施。
