National Institute of Immunohaematology (ICMR), Mumbai, Maharashtra 400012, India.
Hum Pathol. 2013 Oct;44(10):2365-9. doi: 10.1016/j.humpath.2013.02.021. Epub 2013 Jun 4.
Chronic myeloid leukemia (CML) is a hematopoietic stem cell disorder that occurs because of t(9;22)(q34;q11) translocations. Complex translocations have been reported in CML. We report a novel 5-way translocation 46,XY,t(9;11;13;19;22)(9q34.12;11p11.12;13q21.31;19q13.12;22q11.21) using GTG banding, fluorescence in situ hybridization, and spectral karyotyping in a case of chronic-phase CML. Molecular analysis revealed the presence of 2 types of transcripts (b3a2, b2a2). The patient was responding to the imatinib treatment. However, the patient needs to be carefully monitored at various intervals.
慢性髓细胞白血病（CML）是一种造血干细胞疾病，是由于 t(9;22)(q34;q11) 易位引起的。在 CML 中已经报道了复杂的易位。我们报告了一例新型的 5 向易位 46,XY,t(9;11;13;19;22)(9q34.12;11p11.12;13q21.31;19q13.12;22q11.21)，使用 GTG 带，荧光原位杂交和光谱核型分析在慢性期 CML 的病例中。分子分析显示存在 2 种转录本（b3a2，b2a2）。该患者对伊马替尼治疗有反应。但是，需要在不同的时间间隔内仔细监测患者。
