1 Department of Hematology, 2 Department of Hematology, General Hospital of PLA, Beijing 100853, China ; 3 Western Sydney Genomic Diagnostics, Western Sydney Genetics Program, The Children's Hospital at Westmead, NSW, Australia.
Transl Pediatr. 2014 Apr;3(2):135-9. doi: 10.3978/j.issn.2224-4336.2014.01.02.
Spectral karyotyping (SKY) is a novel cytogenetic technique, has been developed to unambiguously display and identify all 24 humans chromosomes at one time without a priori knowledge of any abnormalities involved. SKY can discern the aberrations that can't be detected very well by conventional banding technique and Fluorescent in situ hybridization (FISH). So SKY is hyper accurate, hypersensitive, and hyper intuitionist. We will review the elements and application of SKY in leukemia.
光谱核型分析（SKY）是一种新颖的细胞遗传学技术，它的开发目的是在没有任何先验知识的情况下，一次性清晰地显示和识别所有 24 个人类染色体。SKY 可以辨别常规带型技术和荧光原位杂交（FISH）无法很好检测到的畸变。因此，SKY 具有高度精确性、高灵敏度和高度直观性。我们将回顾 SKY 在白血病中的要素和应用。
