Department of Oral Microbiology, School of Dentistry, Brain Science and Engineering Institute, Kyungpook National University, 2177 Dalgubeol-daero, Jung-gu, Daegu 700-412, South Korea.
Exp Biol Med (Maywood). 2013 Apr;238(4):339-43. doi: 10.1258/ebm.2012.012251.
MicroRNAs (miRNAs) are small, endogenous, non-coding RNAs that regulate the expression of target genes in eukaryotic cells and have been extensively studied in the past decade. However, recent evidence suggests that miRNAs have additional, important roles and functions other than post-transcriptional regulation through binding at the 3' untranslated regions of their target genes. This review describes newly discovered information about the biogenesis and functions of miRNAs as well as presents different points of view about the miRNA system. Our increasing knowledge of the exceptional stories of miRNAs will offer new insights into these powerful gene regulators from virus and bacteria to animals.
微小 RNA（miRNA）是一种小型的、内源性的、非编码 RNA，可在真核细胞中调节靶基因的表达，在过去十年中得到了广泛的研究。然而，最近的证据表明，miRNA 除了通过与靶基因的 3' 非翻译区结合进行转录后调控外，还有其他重要的作用和功能。本文描述了 miRNA 的生物发生和功能的新发现信息，并介绍了 miRNA 系统的不同观点。我们对 miRNA 的特殊故事的认识不断增加，将为这些从病毒和细菌到动物的强大基因调控因子提供新的见解。
