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戊巴比妥可增强蓝斑核神经元中γ-氨基丁酸（GABA）灌流所诱导的电流，但乙醇无此作用。

Enhancement of current induced by superfusion of GABA in locus coeruleus neurons by pentobarbital, but not ethanol.

作者信息

Osmanović S S, Shefner S A

机构信息

Department of Physiology and Biophysics, University of Illinois College of Medicine, Chicago 60612.

出版信息

Brain Res. 1990 May 28;517(1-2):324-9. doi: 10.1016/0006-8993(90)91044-h.

DOI:10.1016/0006-8993(90)91044-h
PMID:2376000
Abstract

gamma-Aminobutyric acid (GABA), pentobarbital and ethanol were applied by bath superfusion to rat locus coeruleus (LC) neurons in a brain slice preparation. The GABA-induced current and conductance increase was measured with single-electrode voltage clamp. Pentobarbital potentiated the GABA-induced current and conductance increase in all LC neurons tested. In contrast, ethanol did not alter the current and conductance increase induced by bath application of GABA to LC neurons.

摘要

在脑片制备中，通过浴槽灌流将γ-氨基丁酸（GABA）、戊巴比妥和乙醇应用于大鼠蓝斑（LC）神经元。采用单电极电压钳测量GABA诱导的电流和电导增加。戊巴比妥增强了所有受试LC神经元中GABA诱导的电流和电导增加。相比之下，乙醇并未改变通过浴槽灌流GABA至LC神经元所诱导的电流和电导增加。

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Enhancement of current induced by superfusion of GABA in locus coeruleus neurons by pentobarbital, but not ethanol.戊巴比妥可增强蓝斑核神经元中γ-氨基丁酸（GABA）灌流所诱导的电流，但乙醇无此作用。
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