通过真正的 Ugi4-CR 构建各种环化支架。
Various cyclization scaffolds by a truly Ugi 4-CR.
机构信息
University of Pittsburgh, Biomedical Science Tower 3, 3501 Fifth Avenue, Pittsburgh, PA 15261, USA.
出版信息
Org Biomol Chem. 2013 Aug 7;11(29):4792-6. doi: 10.1039/c3ob40523k. Epub 2013 Jun 13.
Abstract
Efficient access to a large chemical space based on new scaffolds with defined 3D conformations and highly variable in the side chains is needed to find novel functional materials. Four heterocyclic scaffolds based on a four component Ugi reaction of α-amino acids, oxo components, isocyanides and primary or secondary amines suitably functionalized are described. A handful of examples are described for each scaffold.
摘要
为了寻找新型功能材料，需要基于具有定义的 3D 构象和侧链高度可变性的新骨架，高效地进入广阔的化学空间。本文描述了基于 α-氨基酸、氧代成分、异氰化物和适当官能化的伯或仲胺的四组分 Ugi 反应的四个杂环骨架。每个骨架都描述了少量的例子。
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