Kristofová A, Babinská M, Ujházy E, Nosál R
Ustav experimentálnej farmakológie CFV SAV. Dúbravská, Bratislava.
Bratisl Lek Listy. 1990 Apr;91(4):298-302.
The effect of intragastric administration of pentacaine, a novel Czechoslovak local anesthetic with antiulcer and gastro-protective effect, was studied on the basis of hematological and biochemical parameters in pregnant white New Zealand rabbits. Pentacaine administration in doses of 1, 10, and 50 mg/kg from day 6 to 20 of gestation showed neither signs of toxic effect on hematological parameters, nor did it affect the activity of serum enzymes and the level of glucose, creatinine, urea, and total proteins. The presented results corroborate the safety of pentacaine administration on the applied biomodel.
基于血液学和生化参数，研究了新型捷克斯洛伐克局部麻醉药喷他卡因胃内给药对怀孕的新西兰白兔的影响。在妊娠第6天至20天，以1、10和50mg/kg的剂量给予喷他卡因，结果显示，该药对血液学参数既无毒性作用迹象，也不影响血清酶活性以及葡萄糖、肌酐、尿素和总蛋白水平。上述结果证实了在所应用的生物模型上喷他卡因给药的安全性。
