Ujházy E, Bezek S, Scasnár V, Nosál' R, Majercík M, Valach A
Ustav experimentálnej farmakológie Slovenskej akadémie vied, Bratislava.
Cesk Farm. 1990 Apr;39(2):82-5.
On day 29 of gravidity, the New Zealand white breed rabbits were intravenously administered 3H-pentacaine (0.5 mg.kg-1), a new local anaesthetic agent with anti-ulcerous effect in order to study the distribution in pregnant females. Transplacental passage and a relatively homogenous distribution of unchanged pentacaine were found in the organs of females with the largest accumulation in the lungs. Pentacaine is distributed in the same manner in the fetal organs as in the organs of the mother, but the levels in the foetuses were significantly lower. A morphological study of the rabbit placenta on day 29 of gravidity after the doses of 1, 10 and 50 mg.kg-1 of pentacaine did not show any pathological changes.
在妊娠第29天，给新西兰白兔静脉注射3H-喷他卡因（0.5毫克/千克），这是一种具有抗溃疡作用的新型局部麻醉剂，以研究其在妊娠母兔体内的分布情况。结果发现，喷他卡因可经胎盘转运，且在母兔各器官中分布相对均匀，其中肺中的蓄积量最大。喷他卡因在胎儿器官中的分布方式与母体器官相同，但胎儿体内的药物水平明显较低。在给予1、10和50毫克/千克喷他卡因后，对妊娠第29天的兔胎盘进行形态学研究，未发现任何病理变化。
