Department of Medicine and Haemodialysis Unit, Sultanah Aminah Hospital, Johor Baru, Malaysia.
Kidney Int. 2013 Nov;84(5):1034-40. doi: 10.1038/ki.2013.220. Epub 2013 Jun 12.
In this population-based study, we determine the prevalence of chronic kidney disease in West Malaysia in order to have accurate information for health-care planning. A sample of 876 individuals, representative of 15,147 respondents from the National Health and Morbidity Survey 2011, of the noninstitutionalized adult population (over 18 years old) in West Malaysia was studied. We measured the estimated glomerular filtration rate (eGFR) (CKD-EPI equation); albuminuria and stages of chronic kidney disease were derived from calibrated serum creatinine, age, gender and early morning urine albumin creatinine ratio. The prevalence of chronic kidney disease in this group was 9.07%. An estimated 4.16% had stage 1 chronic kidney disease (eGFR >90 ml/min per 1.73 m(2) and persistent albuminuria), 2.05% had stage 2 (eGFR 60-89 ml/min per 1.73 m(2) and persistent albuminuria), 2.26% had stage 3 (eGFR 30-59 ml/min per 1.73 m(2)), 0.24% had stage 4 (eGFR 15-29 ml/min per 1.73 m(2)), and 0.36% had stage 5 chronic kidney disease (eGFR <15 ml/min per 1.73 m(2)). Only 4% of respondents with chronic kidney disease were aware of their diagnosis. Risk factors included increased age, diabetes, and hypertension. Thus, chronic kidney disease in West Malaysia is common and, therefore, warrants early detection and treatment in order to potentially improve outcome.
在这项基于人群的研究中，我们确定了马来西亚西部的慢性肾脏病患病率，以便为医疗保健规划提供准确的信息。研究对象为马来西亚西部非住院成年人群（18 岁以上）的 15147 名应答者的代表性样本 876 人。我们测量了估算肾小球滤过率（eGFR）（CKD-EPI 方程）；白蛋白尿和慢性肾脏病分期源自校准血清肌酐、年龄、性别和晨尿白蛋白肌酐比值。该组慢性肾脏病的患病率为 9.07%。估计有 4.16%的人患有 1 期慢性肾脏病（eGFR >90 ml/min/1.73 m2且持续白蛋白尿），2.05%的人患有 2 期（eGFR 60-89 ml/min/1.73 m2且持续白蛋白尿），2.26%的人患有 3 期（eGFR 30-59 ml/min/1.73 m2），0.24%的人患有 4 期（eGFR 15-29 ml/min/1.73 m2），0.36%的人患有 5 期慢性肾脏病（eGFR <15 ml/min/1.73 m2）。只有 4%的慢性肾脏病患者知道自己的诊断。危险因素包括年龄增长、糖尿病和高血压。因此，马来西亚西部的慢性肾脏病很常见，因此需要早期发现和治疗，以可能改善预后。
