Peters E M J
Psychoneuroimmunologie Labor, Kliniken für Psychosomatik und Psychotherapie, Justus-Liebig-Universität Gießen, Ludwigstr. 78, 35392 Gießen, Deutschland.
Hautarzt. 2013 Jun;64(6):402-9. doi: 10.1007/s00105-012-2492-y.
Stress and skin-an inseparable pair, this is how many of our patients perceive it and even clinicians are willing to integrate psychosomatic aspects into their recommendations if nothing from the somatic repertoire provides sufficient treatment. How the stress reaches the skin however is still an enigmatic matter to most lay people and professionals alike. Interestingly, psychoneuroimmunological research since the 1970s has produced a flood of valuable data. We now know that stressors, be it biochemical or psychoemotional, always elicit a neuroendocrine stress reaction with consequences for the immune response and therefore especially chronic inflammatory skin diseases. Here we employ allergic inflammation/atopic dermatitis and psoriasis as instructive model diseases to discuss basic mechanisms of molecular psychosomatic effects on chronic inflammation. The aim is to enhance pathogenetic understanding and open the door for the development and employment of integrated therapeutic concepts in dermatology.
压力与皮肤——一对密不可分的组合，这是我们许多患者的认知，甚至临床医生在躯体治疗方法无法提供充分治疗时，也愿意将身心方面的因素纳入他们的建议中。然而，对大多数外行人以及专业人士来说，压力如何影响皮肤仍是个谜。有趣的是，自20世纪70年代以来，心理神经免疫学研究产生了大量有价值的数据。我们现在知道，无论是生化性还是心理情绪性的应激源，都会引发神经内分泌应激反应，进而影响免疫反应，尤其是对慢性炎症性皮肤病产生影响。在这里，我们以过敏性炎症/特应性皮炎和银屑病作为有指导意义的模型疾病，来探讨分子身心效应在慢性炎症中的基本机制。目的是增进对发病机制的理解，并为皮肤科综合治疗理念的发展和应用打开大门。
