Peters Eva M J
Psychoneuroimmunology Laboratory, Department of Psychosomatics Medicine and Psychotherapy, Justus Liebig University, Giessen, Germany.
Charité Center 12 (CC12) for Internal Medicine and Dermatology, Universitätsmedizin - Charité, Berlin, Germany.
J Dtsch Dermatol Ges. 2016 Mar;14(3):233-52; quiz 253. doi: 10.1111/ddg.12957.
A pathogenetically relevant link between stress, in terms of psychosocial stress, and disease was first described in the 1970s, when it was proven that viral diseases of mucous membranes (such as rhinovirus and Coxsackie virus infections) develop faster and more severe after stress exposure. Since then, there has been an annual increase in the number of publications which investigate this relationship and break it down to the molecular level. Nevertheless, the evidences for the impact of psychosocial stress on chronic inflammatory skin diseases and skin tumors are hardly known. In the present review, we outline current insights into epidemiology, psychoneuroimmunology, and molecular psychosomatics which demonstrate the manifold disease-relevant interactions between the endocrine, nervous, and immune systems. The focus is on stress-induced shifts in immune balance in exemplary disorders such as atopic dermatitis, psoriasis, and malignant melanoma. The objective of this article is to convey basic psychosomatic knowledge with respect to etiology, symptomatology, and therapeutic options for chronic skin diseases. Particular attention is directed towards the underlying molecular relationships, both from a somatic to mental as well as a mental to somatic perspective.
20世纪70年代首次描述了心理社会压力方面的应激与疾病之间在病因学上的相关联系，当时已证实应激暴露后黏膜病毒疾病（如鼻病毒和柯萨奇病毒感染）发展得更快且更严重。从那时起，研究这种关系并将其细究到分子水平的出版物数量逐年增加。然而，心理社会压力对慢性炎症性皮肤病和皮肤肿瘤影响的证据却鲜为人知。在本综述中，我们概述了目前在流行病学、心理神经免疫学和分子身心医学方面的见解，这些见解证明了内分泌、神经和免疫系统之间多种与疾病相关的相互作用。重点是应激诱导的免疫平衡变化，如在特应性皮炎、银屑病和恶性黑色素瘤等典型疾病中。本文的目的是传达有关慢性皮肤病的病因、症状和治疗选择的基本身心医学知识。特别关注从躯体到心理以及从心理到躯体角度的潜在分子关系。
