Department of Pediatrics, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, USA,
Curr Allergy Asthma Rep. 2013 Dec;13(6):587-95. doi: 10.1007/s11882-013-0361-0.
The TH17 lineage of T cells and its canonical cytokine IL-17 have been the focus of many recent studies in autoimmune, allergic, and infectious disease. In this review, we will briefly discuss the current knowledge about the role of these cells and IL-17 in a spectrum of disorders. It is clear that IL-17 plays pathogenic roles in certain conditions while the same pathway is critically important to immunity in others. Targeting of TH17 cells or IL-17 therapeutically may impart many benefits, but this approach is not without potentially serious implications regarding host defense. These issues will be discussed herein as we evaluate pharmacological approaches targeting this pathway that are just beginning to be fully tested in human disease.
辅助性 T 细胞 17 谱系及其经典细胞因子白细胞介素-17 一直是自身免疫、过敏和传染病领域众多近期研究的焦点。在这篇综述中，我们将简要讨论目前对这些细胞和白细胞介素-17 在一系列疾病中的作用的了解。很明显，白细胞介素-17 在某些情况下发挥致病性作用，而在其他情况下，同一途径对免疫至关重要。针对 TH17 细胞或白细胞介素-17 的治疗可能会带来许多益处，但这种方法并非没有可能对宿主防御产生严重影响。在评估针对该途径的药理学方法时，我们将讨论这些问题，这些方法才刚刚开始在人类疾病中进行全面测试。
