Larson Rebecca D, McCully Kevin K, Larson Daniel J, Pryor William M, White Lesley J
Department of Health and Exercise Science, University of Oklahoma, Norman, OK 73019, USA.
J Rehabil Res Dev. 2013;50(2):215-22. doi: 10.1682/jrrd.2011.10.0189.
Bilateral differences in lower-limb strength in people with multiple sclerosis (MS) have been clinically observed. The objectives of this study were to quantify bilateral differences in lower-limb performance and metabolism during exercise. Eight ambulatory individuals with mild MS with an Expanded Disability Status Scale score of 2.6 +/- 1.6 and seven non-MS controls completed bilateral assessments of muscle strength and incremental cycling. Individuals with MS had significant (p < 0.05) between-leg differences in leg strength (strong leg: 43.3 +/- 12.7 kg vs weak leg: 37.7 +/- 15.2 kg), peak oxygen uptake (strong leg: 13.7 +/- 3.2 mL/kg/min vs weak leg: 10.6 +/- 3.0 mL/kg/min), and peak workload (strong leg: 73.4 +/- 22.3 W vs weak leg: 56.3 +/- 26.2 W). No between-leg differences were found in controls (p > 0.05). As anticipated, individuals with MS exhibited significantly greater asymmetry for strength, oxygen uptake, and workload than controls (p < 0.05). The differences between legs varied from 2% to 30% for maximal strength and 4% to 66% for cycling workload in the MS group and 4% to 24% and 0% to 8% for the control group, respectively. Preliminary evidence suggests that the magnitude of differences may be related to limitations in aerobic function.
临床上已观察到多发性硬化症（MS）患者双下肢力量存在差异。本研究的目的是量化运动期间双下肢的运动表现和代谢差异。8名轻度MS的非卧床患者，其扩展残疾状态量表评分为2.6±1.6，以及7名非MS对照者完成了肌肉力量和递增式骑行的双侧评估。MS患者两腿之间在腿部力量（健侧：43.3±12.7千克 vs 患侧：37.7±15.2千克）、峰值摄氧量（健侧：13.7±3.2毫升/千克/分钟 vs 患侧：10.6±3.0毫升/千克/分钟）和峰值工作量（健侧：73.4±22.3瓦 vs 患侧：56.3±26.2瓦）方面存在显著差异（p<0.05）。对照组未发现两腿之间存在差异（p>0.05）。正如预期的那样，MS患者在力量、摄氧量和工作量方面的不对称性显著大于对照组（p<0.05）。MS组两腿之间最大力量的差异为2%至30%，骑行工作量的差异为4%至66%；对照组两腿之间最大力量的差异为4%至24%，骑行工作量的差异为0%至8%。初步证据表明，差异的大小可能与有氧功能的限制有关。
