Dermatology Service, Tripler Army Medical Center, Honolulu, HI 96859, USA.
Lupus. 2013 Jul;22(8):851-4. doi: 10.1177/0961203313492243. Epub 2013 Jun 11.
Lupus erythematosus/lichen planus overlap syndrome is a rare disorder combining the clinical, histological and immunopathological features of both lupus erythematosus (LE) and lichen planus (LP). Cutaneous lesions mostly affect the distal arms, legs, face and trunk. Palmoplantar involvement is felt to be characteristic of this condition. Plaques are often painful, centrally atrophic, bluish-red to hypopigmented in color, large, and scaly. On biopsy of clinically ambiguous lesions, histopathological features of one or both processes can be found, obscuring the diagnosis and complicating prognosis and treatment. Thus, direct immunofluorescence has become an essential tool in helping to diagnose this condition. In this report we describe the unique clinical and immunohistopathological manifestations of lupus erythematosus/lichen planus overlap syndrome along with a successful response to treatment with acitretin.
红斑狼疮/扁平苔藓重叠综合征是一种罕见的疾病，结合了红斑狼疮 (LE) 和扁平苔藓 (LP) 的临床、组织学和免疫病理学特征。皮肤损伤主要影响远端手臂、腿部、面部和躯干。手掌足底受累被认为是这种情况的特征。斑块通常疼痛，中央萎缩，呈蓝红色至色素减退，大而鳞片状。在临床上有疑问的病变的活检中，可以发现一个或两个过程的组织病理学特征，这使得诊断变得模糊，并使预后和治疗复杂化。因此，直接免疫荧光已成为帮助诊断这种情况的重要工具。在本报告中，我们描述了红斑狼疮/扁平苔藓重叠综合征的独特临床和免疫组织病理学表现，并成功地用阿维 A 酯治疗。
