怀孕灵长类动物吸入4%和8%氟烷的效果比较。

A comparison of the effects of the inhalation of 4% and 8% fluroxene in the pregnant primate.

作者信息

Eng M, Berges P U, Yuen D D, Bonica J J, Ueland K

出版信息

Acta Anaesthesiol Scand. 1976;20(2):183-8. doi: 10.1111/j.1399-6576.1976.tb05026.x.

DOI:10.1111/j.1399-6576.1976.tb05026.x

Abstract

A comparison was made of the effects of inhalation of 4% fluroxene (n = 5) and 8% fluroxene (n = 5) in pregnant monkeys. Measurements of maternal arterial blood pressure, heart rate, cardiac output, total peripheral resistance, uterine blood flow, fetal heart rate and arterial blood pressure, and maternal and fetal blood gas levels were made. Inhalation of 4% fluroxene for 20 minutes produced little change in maternal hemodynamics and was well tolerated by the fetus. Fluroxene 8% inhaled for a similar 20-minute-period produced a significant decrease in maternal blood pressure (--27%), total peripheral resistance (--32%), and uterine blood flow (--27%) and lowered the level of maternal fetal exchange.

摘要

对怀孕猴子吸入4%氟烷（n = 5）和8%氟烷（n = 5）的效果进行了比较。测量了母体动脉血压、心率、心输出量、总外周阻力、子宫血流量、胎儿心率和动脉血压，以及母体和胎儿的血气水平。吸入4%氟烷20分钟对母体血流动力学影响很小，胎儿耐受性良好。吸入8%氟烷20分钟，母体血压显著下降（-27%）、总外周阻力（-32%）和子宫血流量（-27%），并降低了母体与胎儿之间的物质交换水平。