Desrochers Dan, González-Peralta Regino P, McClenathan Daniel T, Wilsey Michael J, Haafiz Allah
Department of Pediatrics, University of South Florida College of Medicine, Tampa, Florida, USA.
Clin Med Insights Pediatr. 2011 Mar 23;5:9-13. doi: 10.4137/CMPed.S6406. Print 2011.
Isoniazid (INH) monotherapy has gained widespread acceptance as an efficacious therapy for latent tuberculosis infection (LTBI) especially in low-prevalence settings. Although INH related hepatotoxicity is well recognized, progression to severe liver dysfunction requiring care at a transplant center remains unpredictable. We report the management of a five year-old girl who developed progressive liver failure due to INH prophylaxis. This highlights the potential severity of INH related hepatic injury and underscores the significance of vigilant clinical monitoring throughout the duration of the therapy in children.
异烟肼（INH）单一疗法作为潜伏性结核感染（LTBI）的一种有效治疗方法已得到广泛认可，尤其是在低发病率地区。尽管异烟肼相关的肝毒性已广为人知，但进展为需要在移植中心接受治疗的严重肝功能障碍仍然无法预测。我们报告了一名五岁女孩因预防性使用异烟肼而发生进行性肝衰竭的治疗情况。这突出了异烟肼相关肝损伤的潜在严重性，并强调了在儿童治疗期间进行密切临床监测的重要性。
