Child Growth and Development Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
J Environ Public Health. 2013;2013:142856. doi: 10.1155/2013/142856. Epub 2013 May 16.
This study aimed to determine the association of blood cadmium level with cardiometabolic risk factors and liver enzymes in adolescents.
This case control study comprised 320 Iranian adolescents, 160 with metabolic syndrome and an equal number of controls. They were selected from participants of a nationwide survey entitled the CASPIAN-III study. Cadmium was measured by atomic absorption method.
The mean age of the case and control groups was not significantly different (15.3 ± 2.6 versus 14.63 ± 2.5 years, resp., P > 0.05). The mean cadmium level was near double-fold higher than the standards of the World Health Organization, without significant difference between the MetS and control groups (10.09 ± 2.21, 9.97 ± 2.38 μ g/L, resp., P > 0.05). Cadmium level had positive but nonsignificant correlations with diastolic blood pressure, serum triglycerides, fasting blood glucose, LDL-C, and liver enzymes.
Cadmium level had positive but nonsignificant association with some cardiometabolic risk factors and liver enzymes. The associations did not reach statistical significant level, and this may be because of the high levels of cadmium in both groups studied or because of the young age group of participants. Controlling environmental pollutants shall be a priority for the prevention of chronic diseases.
本研究旨在确定血液中镉水平与青少年代谢相关心血管危险因素和肝酶之间的关系。
本病例对照研究纳入了 320 名伊朗青少年，其中 160 名患有代谢综合征，另外 160 名为对照组。他们均选自全国性调查“伊朗儿童青少年心血管危险因素研究（CASPIAN-III）”的参与者。采用原子吸收法测量镉含量。
病例组和对照组的平均年龄无显著差异（15.3±2.6 岁对 14.63±2.5 岁，P＞0.05）。两组的平均镉水平均接近世界卫生组织标准的两倍，但代谢综合征组和对照组之间无显著差异（10.09±2.21μg/L 对 9.97±2.38μg/L，P＞0.05）。镉水平与舒张压、血清甘油三酯、空腹血糖、LDL-C 和肝酶呈正相关，但无统计学意义。
镉水平与一些代谢相关心血管危险因素和肝酶呈正相关，但无统计学意义。这可能是由于研究组的镉水平较高，或者由于参与者年龄较小。控制环境污染物应是预防慢性病的优先事项。
