Maes Roger
Departments of Pathobiology and Diagnostic Investigation and Microbiology and Molecular Genetics, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, USA.
ISRN Vet Sci. 2012 Nov 14;2012:495830. doi: 10.5402/2012/495830. Print 2012.
Feline herpesvirus 1 (FeHV-1) is an alphaherpesvirus that causes feline viral rhinotracheitis, an important viral disease of cats on a worldwide basis. Acute FeHV-1 infection is associated with both upper respiratory and ocular signs. Following the acute phase of the disease lifelong latency is established, primarily in sensory neuronal cells. As is the case with human herpes simplex viruses, latency reactivation can result in recrudescence, which can manifest itself in the form of serious ocular lesions. FeHV-1 infection in cats is a natural host model that is useful for the identification of viral virulence genes that play a role in replication at the mucosal portals of entry or are mediators of the establishment, maintenance, or reactivation of latency. It is also a model system for defining innate and adaptive immunity mechanisms and for immunization strategies that can lead to better protection against this and other alphaherpesvirus infections.
猫疱疹病毒1型（FeHV-1）是一种α疱疹病毒，可引起猫病毒性鼻气管炎，这是一种在全球范围内对猫来说很重要的病毒性疾病。FeHV-1急性感染与上呼吸道和眼部症状都有关。在疾病的急性期过后，会建立终身潜伏感染，主要发生在感觉神经元细胞中。和人类单纯疱疹病毒的情况一样，潜伏感染的重新激活可导致复发，这可能以严重眼部病变的形式表现出来。猫的FeHV-1感染是一种天然宿主模型，有助于鉴定在黏膜入口处复制中起作用或在潜伏感染的建立、维持或重新激活中起介导作用的病毒毒力基因。它也是一个用于定义先天性和适应性免疫机制以及免疫策略的模型系统，这些免疫策略可带来针对这种及其他α疱疹病毒感染的更好保护。
