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接种猫疱疹病毒1型减毒活疫苗的猫的细胞免疫和体液免疫反应。

Cellular and humoral immune responses in cats vaccinated with feline herpesvirus 1 modified live virus vaccine.

作者信息

Wu Hongchao, Qiao Peipei, Chen Yunyu, Liu Caihong, Huo Ningning, Ding Hangtian, Wang Xiaojuan, Wang Lulu, Xi Xiangfeng, Liu Yuxiu, Tian Kegong

机构信息

College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, China.

National Research Center for Veterinary Medicine, Luoyang, China.

出版信息

Front Vet Sci. 2025 Jan 15;11:1516850. doi: 10.3389/fvets.2024.1516850. eCollection 2024.

DOI:10.3389/fvets.2024.1516850
PMID:39881722
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11775014/
Abstract

Feline herpesvirus 1 (FHV-1) is an important pathogen causing infectious rhinotracheitis in felids, mainly infecting the upper respiratory tract and conjunctiva. Multiple vaccines are available to prevent FHV-1 infection, and the antibody levels are always used to evaluate their effectiveness. However, the cellular immunity response following immunization in cats remains unclear. This study investigated the immune responses (humoral and cellular) in cats immunized with the FHV-1 modified live virus vaccine. The results indicated that vaccination significantly reduced clinical signs, and antibody levels, including virus-neutralizing (VN) antibodies and immunoglobulin G (IgG), in the vaccine group were higher than those in the control groups. Additionally, the vaccine significantly increased cytokine secretion, indicating Th1-type cellular immune responses in cats. Moreover, cellular immune-related indicators, such as CD8+ T cells, CD4+ T cells, and interferon-gamma levels, were inversely correlated with clinical signs post-challenge by FHV-1 in vaccinated cats, highlighting its crucial role in protecting cats against FHV-1 infection. In summary, this study demonstrated the importance of cellular immune responses in protecting cats from FHV-1 infection after vaccination.

摘要

猫疱疹病毒1型（FHV - 1）是引起猫科动物传染性鼻气管炎的重要病原体，主要感染上呼吸道和结膜。有多种疫苗可用于预防FHV - 1感染，并且抗体水平一直被用于评估其有效性。然而，猫免疫后的细胞免疫反应仍不清楚。本研究调查了用FHV - 1减毒活疫苗免疫的猫的免疫反应（体液免疫和细胞免疫）。结果表明，疫苗接种显著减轻了临床症状，疫苗组的抗体水平，包括病毒中和（VN）抗体和免疫球蛋白G（IgG），高于对照组。此外，疫苗显著增加了细胞因子分泌，表明猫体内存在Th1型细胞免疫反应。而且，细胞免疫相关指标，如CD8 + T细胞、CD4 + T细胞和干扰素 - γ水平，与接种疫苗的猫在受到FHV - 1攻击后的临床症状呈负相关，突出了其在保护猫免受FHV - 1感染中的关键作用。总之，本研究证明了细胞免疫反应在疫苗接种后保护猫免受FHV - 1感染中的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01f7/11775014/3870401b0291/fvets-11-1516850-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01f7/11775014/01528be7be94/fvets-11-1516850-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01f7/11775014/9efa167ee2a5/fvets-11-1516850-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01f7/11775014/74c73bf3654b/fvets-11-1516850-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01f7/11775014/3870401b0291/fvets-11-1516850-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01f7/11775014/01528be7be94/fvets-11-1516850-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01f7/11775014/c52d50aee2a3/fvets-11-1516850-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01f7/11775014/bd677d48bd0a/fvets-11-1516850-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01f7/11775014/9efa167ee2a5/fvets-11-1516850-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01f7/11775014/74c73bf3654b/fvets-11-1516850-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01f7/11775014/3870401b0291/fvets-11-1516850-g006.jpg

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