Kawasaki Amie, Corey Elizabeth G, Laskey Robin A, Weidner Alison C, Siddiqui Nazema Y, Wu Jennifer M
Department of Obstetrics and Gynecology, Duke University Medical Center, Box 3192, 5324 McFarland Drive, Suite 300, Durham, NC 27707, USA.
J Reprod Med. 2013 May-Jun;58(5-6):195-9.
To determine whether obese body mass index is associated with the recurrence of anterior vaginal wall prolapse after anterior colporrhaphy.
We conducted a retrospective cohort study of the risk of recurrent anterior prolapse 6 months after anterior colporrhaphy in normal weight/overweight versus obese women from January 2004 to December 2010. Women who underwent a concurrent apical prolapse procedure were excluded. Data were abstracted regarding sociodemographics, physical examination, operative reports, and postoperative follow-up visits.
Of 282 subjects 192 (68%) were normal/overweight and 90 (32%) were obese. Median time of follow-up was 1.8 months (interquartile range [IQR] 1.4-6.2) in the normal/overweight group and 2.0 months (IQR 1.4-5.9) in the obese group. The overall risk of recurrent prolapse was 15.2%. In bivariate analysis there was a trend towards higher recurrence in the obese versus the normal/overweight cohort (21.1% vs. 12.5%, p = 0.06). In the logistic regression model, which adjusted for age, race, diabetes, constipation, cigarette use, concurrent sling, and prior hysterectomy, obesity became significantly associated with recurrent anterior prolapse (odds ratio 2.5, 95% confidence interval 1.2-5.3).
The risk of recurrence after anterior colporrhaphy is relatively high in the short-term. Obesity is associated with increased odds of anatomic recurrence of anterior vaginal wall prolapse.
确定肥胖体重指数是否与阴道前壁修补术后阴道前壁脱垂复发相关。
我们对2004年1月至2010年12月体重正常/超重与肥胖女性阴道前壁修补术后6个月前壁脱垂复发风险进行了一项回顾性队列研究。同时进行了顶端脱垂手术的女性被排除在外。提取了有关社会人口统计学、体格检查、手术报告和术后随访的数据。
282名受试者中,192名(68%)体重正常/超重,90名(32%)肥胖。正常/超重组的中位随访时间为1.8个月(四分位间距[IQR]1.4 - 6.2),肥胖组为2.0个月(IQR 1.4 - 5.9)。复发脱垂的总体风险为15.2%。在双变量分析中,肥胖组与正常/超重队列相比有更高复发率的趋势(21.1%对12.5%,p = 0.06)。在调整了年龄、种族、糖尿病、便秘、吸烟、同时使用吊带和既往子宫切除术的逻辑回归模型中,肥胖与阴道前壁脱垂复发显著相关(比值比2.5,95%置信区间1.2 - 5.3)。
阴道前壁修补术后短期内复发风险相对较高。肥胖与阴道前壁脱垂解剖学复发几率增加相关。