University of California, Los Angeles, Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, 760 Westwood Plaza, 38-260, Los Angeles, CA 90024-1759, USA.
Am J Public Health. 2013 Aug;103(8):1476-84. doi: 10.2105/AJPH.2012.301121. Epub 2013 Jun 13.
HIV transmission risk is high among men who have sex with men and women (MSMW), and it is further heightened by a history of childhood sexual abuse (CSA) and current traumatic stress or depression. Yet, traumatic stress is rarely addressed in HIV interventions. We tested a stress-focused sexual risk reduction intervention for African American MSMW with CSA histories.
This randomized controlled trial compared a stress-focused sexual risk reduction intervention with a general health promotion intervention. Sexual risk behaviors, psychological symptoms, stress biomarkers (urinary cortisol and catecholamines), and neopterin (an indicator of HIV progression) were assessed at baseline and at 3- and 6-month follow-ups.
Both interventions decreased and sustained reductions in sexual risk and psychological symptoms. The stress-focused intervention was more efficacious than the general health promotion intervention in decreasing unprotected anal insertive sex and reducing depression symptoms. Despite randomization, baseline group differences in CSA severity, psychological symptoms, and biomarkers were found and linked to subsequent intervention outcomes.
Although interventions designed specifically for HIV-positive African American MSMW can lead to improvements in health outcomes, future research is needed to examine factors that influence intervention effects.
男男性行为者和女性(MSMW)中的 HIV 传播风险很高,而童年性虐待(CSA)和当前创伤性应激或抑郁的历史会进一步加剧这种风险。然而,在 HIV 干预措施中,创伤性应激很少得到解决。我们测试了一种针对有 CSA 历史的非裔美国 MSMW 的以压力为重点的性风险降低干预措施。
这项随机对照试验比较了以压力为重点的性风险降低干预措施与一般健康促进干预措施。在基线和 3 个月和 6 个月的随访中,评估了性风险行为、心理症状、压力生物标志物(尿皮质醇和儿茶酚胺)和新蝶呤(HIV 进展的指标)。
两种干预措施都减少并持续减少了性风险和心理症状。与一般健康促进干预相比,以压力为重点的干预措施更能有效减少无保护的肛门插入性行为和减少抑郁症状。尽管进行了随机分组,但仍发现了基线组间 CSA 严重程度、心理症状和生物标志物的差异,并与随后的干预结果相关。
尽管专为 HIV 阳性非裔美国 MSMW 设计的干预措施可以改善健康结果,但仍需要研究影响干预效果的因素。