Ramage Gordon, Williams Craig
Infection and Immunity Research Group, Glasgow Dental School, School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.
Adv Appl Microbiol. 2013;84:27-83. doi: 10.1016/B978-0-12-407673-0.00002-3.
Fungal biofilms have become an increasingly important clinical problem. The widespread use of antibiotics, frequent use of indwelling medical devices, and a trend toward increased patient immunosuppression have resulted in a creation of opportunity for clinically important yeasts and molds to form biofilms. This review will discuss the diversity and importance of fungal biofilms in the context of clinical medicine, provide novel insights into the clinical management of fungal biofilm infection, present evidence why these structures are recalcitrant to antifungal therapy, and discuss how our knowledge and understanding may lead to novel therapeutic intervention.
真菌生物膜已成为一个日益重要的临床问题。抗生素的广泛使用、留置医疗设备的频繁使用以及患者免疫抑制增加的趋势，为具有临床重要性的酵母和霉菌形成生物膜创造了机会。本综述将在临床医学背景下讨论真菌生物膜的多样性和重要性，提供关于真菌生物膜感染临床管理的新见解，阐述这些结构对抗真菌治疗具有抗性的证据，并讨论我们的知识和理解如何可能带来新的治疗干预措施。
