Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA.
Prog Mol Biol Transl Sci. 2013;118:359-93. doi: 10.1016/B978-0-12-394440-5.00014-0.
β-Arrestins regulate G protein-coupled receptors through receptor desensitization while also acting as signaling scaffolds to facilitate numerous effector pathways. Recent studies have provided evidence that β-arrestins play a key role in inflammatory responses. Here, we summarize these advances on the roles of β-arrestins in immune regulation and inflammatory responses under physiological and pathological conditions, with an emphasis on translational implications of β-arrestins on human diseases.
β-arrestins 通过受体脱敏调节 G 蛋白偶联受体，同时作为信号支架促进众多效应途径。最近的研究提供了证据表明β-arrestins 在炎症反应中发挥关键作用。在这里，我们总结了β-arrestins 在生理和病理条件下免疫调节和炎症反应中的作用的这些进展，重点介绍了β-arrestins 对人类疾病的转化意义。
