Sharma D, Parameswaran N
Department of Physiology and Division of Pathology, Michigan State University, East Lansing, MI, USA.
Genes Immun. 2015 Dec;16(8):499-513. doi: 10.1038/gene.2015.37. Epub 2015 Sep 17.
Arrestins are intracellular scaffolding proteins known to regulate a range of biochemical processes including G protein-coupled receptor (GPCR) desensitization, signal attenuation, receptor turnover and downstream signaling cascades. Their roles in regulation of signaling network have lately been extended to receptors outside of the GPCR family, demonstrating their roles as important scaffolding proteins in various physiological processes including proliferation, differentiation and apoptosis. Recent studies have demonstrated a critical role for arrestins in immunological processes including key functions in inflammatory signaling pathways. In this review, we provide a comprehensive analysis of the different functions of the arrestin family of proteins especially related to immunity and inflammatory diseases.
抑制蛋白是细胞内的支架蛋白，已知其可调节一系列生化过程，包括G蛋白偶联受体（GPCR）脱敏、信号衰减、受体周转和下游信号级联反应。它们在信号网络调节中的作用最近已扩展到GPCR家族之外的受体，表明它们在包括增殖、分化和凋亡在内的各种生理过程中作为重要支架蛋白的作用。最近的研究表明，抑制蛋白在免疫过程中起关键作用，包括在炎症信号通路中的关键功能。在这篇综述中，我们对抑制蛋白家族蛋白质的不同功能进行了全面分析，尤其与免疫和炎症性疾病相关。
