Schauer Steven G, Varney Shawn M
Department of Emergency Medicine, San Antonio Military Medical Center-North, 3851 Roger Brooke Drive, Fort Sam Houston, TX 78234, USA.
Mil Med. 2013 Jan;178(1):e133-5. doi: 10.7205/MILMED-D-12-00301.
We report the case of a 59-year-old military beneficiary that presented to the emergency department after ingesting approximately 90 g of gabapentin immediate-release capsules during a deliberate self-harm attempt. Her serum gabapentin level was 72.8 mcg/mL approximately 3 hours after ingestion. Her renal function panel, complete blood count, and liver function panel were normal. Her urine drug screen, aspirin, ethanol, and acetaminophen level were negative. Her electrocardiogram was normal, including a normal QTc interval. Her only symptoms were nausea and mild sedation. She was admitted for observation with no sequelae noted. She was transferred to a psychiatric facility at that time for further evaluation and treatment. We report a case of gabapentin overdose that presented to the emergency department. Given the large volume ingestion with minimal morbidity, it appears that gabapentin has a wide therapeutic margin and may be safe in overdose.
我们报告一例59岁的军队受益人的病例，该患者在蓄意自残尝试中摄入约90克加巴喷丁速释胶囊后前往急诊科就诊。摄入后约3小时，她的血清加巴喷丁水平为72.8 mcg/mL。她的肾功能指标、全血细胞计数和肝功能指标均正常。她的尿液药物筛查、阿司匹林、乙醇和对乙酰氨基酚水平均为阴性。她的心电图正常，包括QTc间期正常。她仅有的症状是恶心和轻度镇静。她入院观察，未发现后遗症。当时她被转至精神科机构进行进一步评估和治疗。我们报告了一例前往急诊科就诊的加巴喷丁过量病例。鉴于大量摄入但发病率极低，看来加巴喷丁具有较宽的治疗窗，过量时可能是安全的。
