人溶菌酶抑制 Aβ 肽的体外聚集，而 Aβ 肽在体内与阿尔茨海默病有关。
Human lysozyme inhibits the in vitro aggregation of Aβ peptides, which in vivo are associated with Alzheimer's disease.
机构信息
Gorlaeus Laboratory, Leiden Institute of Chemistry, Leiden University, 2300RA Leiden, The Netherlands.
出版信息
Chem Commun (Camb). 2013 Jul 25;49(58):6507-9. doi: 10.1039/c3cc42325e. Epub 2013 Jun 13.
PMID:23764522
Abstract
Alzheimer's disease is a neurodegenerative disorder characterized by accumulation of Aβ peptide aggregates in the brain. Using ThT fluorescence assays, AFM imaging, NMR and CD spectroscopy, and MD modeling we show that lysozyme - a hydrolytic enzyme abundant in human secretions - completely inhibits the aggregation of Aβ peptides at equimolar lysozyme : Aβ peptide ratios.
摘要
阿尔茨海默病是一种神经退行性疾病，其特征是大脑中 Aβ 肽聚集物的积累。通过使用 ThT 荧光分析、原子力显微镜成像、NMR 和 CD 光谱以及 MD 建模，我们表明溶菌酶——一种在人类分泌物中丰富的水解酶——在等摩尔溶菌酶：Aβ 肽比例下完全抑制 Aβ 肽的聚集。
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