Laboratory of Chemical Biology, Division of Biological Inorganic Chemistry, State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Changchun 130022, China.
Small. 2013 Jan 14;9(1):52-5. doi: 10.1002/smll.201201543. Epub 2012 Sep 14.
A cationic perylene tetracarboxylic acid diimide derivative (1) is employed as a probe for in situ monitoring of Aβ aggregation and screening Aβ inhibitors. The assay is based on the fluorescence change through the aggregation of compound 1 following Aβ assembly. Importantly, this probe, compared with the well known amyloid-staining compound thioflavin T (ThT), is more sensitive to Aβ oligomer, which is highly toxic and plays a crucial role in the early stages of Alzheimer's disease.
一种阳离子苝四羧酸二酰亚胺衍生物（1）被用作原位监测 Aβ 聚集和筛选 Aβ 抑制剂的探针。该测定法基于 Aβ 组装后化合物 1 聚集引起的荧光变化。重要的是，与众所周知的淀粉样蛋白染色化合物噻唑蓝 T（ThT）相比，该探针对 Aβ 低聚物更敏感，Aβ 低聚物具有高毒性，并且在阿尔茨海默病的早期阶段发挥关键作用。
