Department of Obstetrics and Gynecology, New York University, New York, NY 10016, USA.
J Trop Pediatr. 2013 Dec;59(6):441-6. doi: 10.1093/tropej/fmt044. Epub 2013 Jun 13.
As human immunodeficiency virus (HIV)-infected women gain access to combination antiretroviral therapy throughout sub-Saharan Africa, a growing number of infants are being born HIV-exposed but uninfected. Data about neonatal mortality and the impact of premature delivery, in this population are limited. We describe the 28-day mortality outcomes in a cohort of HIV-exposed infants who had ultrasound-confirmed gestational age in rural Uganda. There were 13 deaths among 351 infants, including 9 deaths in the perinatal period. Premature delivery was a strong predictor of mortality. The prevention of HIV transmission to infants is now possible in rural low-resource settings but the frequency of neonatal death among HIV-exposed infants remains extremely high, calling for new comprehensive interventions to reduce mortality in this growing population.
随着抗逆转录病毒疗法在撒哈拉以南非洲的普及，越来越多的艾滋病病毒感染者的婴儿出生时并未感染艾滋病病毒。但目前，有关这一人群的新生儿死亡率和早产影响的数据有限。我们描述了在乌干达农村地区的一个经超声确认胎龄的艾滋病病毒暴露婴儿队列的 28 天死亡率结果。在 351 名婴儿中，有 13 人死亡，其中 9 人死于围产期。早产是死亡的一个强有力的预测因素。在资源匮乏的农村地区，现在已经可以预防艾滋病病毒母婴传播，但艾滋病病毒暴露婴儿的新生儿死亡率仍然极高，这需要新的综合干预措施来降低这一不断增长的人群的死亡率。
