¹⁸F-氟脱氧葡萄糖正电子发射断层扫描检测到的甲状腺局灶性偶然摄取。患病率和恶性风险的荟萃分析。
Focal thyroid incidental uptake detected by ¹⁸F-fluorodeoxyglucose positron emission tomography. Meta-analysis on prevalence and malignancy risk.
作者信息
Treglia G, Bertagna F, Sadeghi R, Verburg F A, Ceriani L, Giovanella L
机构信息
Department of Nuclear Medicine and Thyroid Center, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland.
出版信息
Nuklearmedizin. 2013;52(4):130-6. doi: 10.3413/Nukmed-0568-13-03. Epub 2013 Jun 14.
AIM
To perform a meta-analysis of published data on the prevalence and risk of malignancy of focal thyroid incidental uptake (FTIs) detected by Fluorine-18-Fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) or PET/CT.
METHODS
A comprehensive literature search of studies published up to and including December 2012 was performed. Pooled prevalence and malignancy risk of FTIs were calculated, including a sub-analysis for the geographic areas of origin of the studies.
RESULTS
34 studies including 215,057 patients were selected. Pooled prevalence of FTIs was 1.92% (95% confidence interval [95%CI]: 1.87-1.99%). Overall, 1522 FTIs underwent histopathology evaluation. Pooled risk of malignancy was 36.2% (95%CI: 33.8-38.6%), without significant differences among various geographic areas.
CONCLUSIONS
FTIs are observed in about 2% of 18F-FDG-PET or PET/CT scans and carry a significant risk of malignancy. Therefore, further investigation is warranted whenever FTIs are detected by 18F-FDG-PET or PET/CT.
目的
对已发表的关于通过氟-18-氟脱氧葡萄糖（18F-FDG）正电子发射断层扫描（PET）或PET/CT检测到的局灶性甲状腺偶然摄取（FTIs）的患病率和恶性风险的数据进行荟萃分析。
方法
对截至2012年12月（含）发表的研究进行全面的文献检索。计算FTIs的合并患病率和恶性风险，包括对研究来源地理区域的亚分析。
结果
选择了34项研究，包括215,057名患者。FTIs的合并患病率为1.92%（95%置信区间[95%CI]：1.87 - 1.99%）。总体而言，1522例FTIs接受了组织病理学评估。恶性风险合并率为36.2%（95%CI：33.8 - 38.6%），不同地理区域之间无显著差异。
结论
在约2%的18F-FDG-PET或PET/CT扫描中观察到FTIs，且其具有显著的恶性风险。因此，当通过18F-FDG-PET或PET/CT检测到FTIs时，有必要进行进一步调查。
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