Tsuda T, Nagira T, Yamamoto M, Kume Y
Oita Kyouwa Hospital, Japan.
Ind Health. 1990;28(2):53-62. doi: 10.2486/indhealth.28.53.
A mortality study has been made to assess the carcinogenic effect of arsenic exposure by analyzing a group of certified chronic arsenic poisoning patients at a small mining village in Japan. When compared with expected number of deaths, based on sex-, age-specific mortality of Japanese in 1975, '80 and '85, all cancer, cancer of respiratory system and cancer of bladder, kidney and other and unspecified urinary organs showed a significant excess over the expected number. Divided by employment history, death due to all cancers, to respiratory cancer and to urinary tract cancer showed a significant excess among former workers of the mine. Classified into four cohorts by both employment history and smoking habit, death from respiratory cancer showed a significant excess only in the cohort respiratory cancer showed a significant excess only in the cohort of former workers with smoking history, suggesting an interaction between exposure to arsenic and smoking. Eight cases among ten respiratory cancers and two urinary tract cancer cases were accompanied by cancer of other organs, including Bowen's disease.
通过分析日本一个小矿村一组经认证的慢性砷中毒患者，进行了一项死亡率研究，以评估砷暴露的致癌作用。与基于1975年、1980年和1985年日本按性别和年龄划分的死亡率预期死亡人数相比，所有癌症、呼吸系统癌症以及膀胱、肾脏和其他及未指明泌尿器官的癌症，均显示出显著高于预期人数。按就业史划分，所有癌症、呼吸道癌症和泌尿系统癌症导致的死亡在该矿的前工人中显著高于预期。按就业史和吸烟习惯分为四个队列，仅在有吸烟史的前工人队列中，呼吸道癌症死亡人数显著高于预期，这表明砷暴露与吸烟之间存在相互作用。十例呼吸道癌症中有八例以及两例泌尿系统癌症病例伴有包括鲍恩病在内的其他器官癌症。
