Omae K, Sakurai H, Higashi T, Muto T, Ichikawa M, Sasaki N
Department of Preventive Medicine and Public Health, School of Medicine, Keio University, Tokyo, Japan.
Ind Health. 1990;28(2):77-83. doi: 10.2486/indhealth.28.77.
A cross-sectional study was performed on 165 male lead-exposed workers to clarify the quantitative relationships between less severe exposure to lead and its effects on renal function in 1985. Mean and range of blood lead concentration (Pb-B) were 36.5 micrograms/dl and 6-73 micrograms/dl, respectively. Duration of lead exposure was 0.1 to 26.3 years. No lead-related changes were detected in serum creatinine concentration, beta-2 microglobulin in urine, creatinine clearance, beta-2 microglobulin clearance, and uric acid clearance. Twenty of the 165 workers had been exposed to lead for more than 10 years with mean duration of 21.0 years. Average concentrations of Pb-B in each individual during 1972 to 1984 were 26.1-66.6 micrograms/dl. Renal function indices of these 20 workers were not different from those of remaining lead-exposed workers whose lead exposure duration were 10 years or less. These results suggest that long-term less severe exposure to lead up to 70 micrograms/dl of Pb-B may not cause adverse effects on renal glomerular function and proximal tubular function.
1985年，对165名男性铅接触工人进行了一项横断面研究，以阐明轻度铅接触与其对肾功能影响之间的定量关系。血铅浓度（Pb-B）的平均值和范围分别为36.5微克/分升和6 - 73微克/分升。铅接触时间为0.1至26.3年。血清肌酐浓度、尿β2微球蛋白、肌酐清除率、β2微球蛋白清除率和尿酸清除率均未检测到与铅相关的变化。165名工人中有20人接触铅超过10年，平均接触时间为21.0年。1972年至1984年期间，每个人的Pb-B平均浓度为26.1 - 66.6微克/分升。这20名工人的肾功能指标与其余铅接触时间为10年或更短的铅接触工人没有差异。这些结果表明，长期轻度接触铅（Pb-B高达70微克/分升）可能不会对肾小球功能和近端小管功能产生不良影响。
