• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Rh(III)-催化的（杂）芳基与烯丙醇的脱氢烷基化反应，可实现与茚的羟醛缩合。

Rh(III)-catalyzed dehydrogenative alkylation of (hetero)arenes with allylic alcohols, allowing aldol condensation to indenes.

机构信息

Universität Münster Organisch-Chemisches Institut, Corrensstrasse 40, 48149 Münster, Germany.

出版信息

Chem Commun (Camb). 2013 Jul 25;49(58):6489-91. doi: 10.1039/c3cc43903h. Epub 2013 Jun 14.

DOI:10.1039/c3cc43903h
PMID:23765402
Abstract

Efficient Rh(III)-catalyzed C-H activation of different classes of (hetero)arenes such as 2-phenylpyridine, indoles, aryl ketones and acetanilide and their dehydrogenative cross-coupling with allylic alcohols are described. Several important skeletons such as β-aryl aldehydes and ketones, 2-acetylindenes, 3,4-dihydro-1H-quinolin-2-one and quinoline could be produced using this protocol.

摘要

描述了高效的 Rh(III)-催化不同类型（杂）芳基 C-H 活化，如 2-苯基吡啶、吲哚、芳基酮和乙酰苯胺，以及它们与烯丙醇的脱氢交叉偶联。该方法可用于生成多种重要骨架，如β-芳基醛和酮、2-乙酰基茚、3,4-二氢-1H-喹啉-2-酮和喹啉。

相似文献

1
Rh(III)-catalyzed dehydrogenative alkylation of (hetero)arenes with allylic alcohols, allowing aldol condensation to indenes.Rh(III)-催化的（杂）芳基与烯丙醇的脱氢烷基化反应，可实现与茚的羟醛缩合。
Chem Commun (Camb). 2013 Jul 25;49(58):6489-91. doi: 10.1039/c3cc43903h. Epub 2013 Jun 14.
2
Rh(III)-Catalyzed Acceptorless Dehydrogenative Coupling of (Hetero)arenes with 2-Carboxyl Allylic Alcohols.Rh(III)-催化的（杂）芳基与 2-羧酸烯丙醇的无受体脱氢偶联反应。
Org Lett. 2018 Feb 2;20(3):740-743. doi: 10.1021/acs.orglett.7b03881. Epub 2018 Jan 18.
3
Aerobic oxidative coupling between carbon nucleophiles and allylic alcohols: a strategy to construct β-(hetero)aryl ketones and aldehydes through hydrogen migration.碳亲核试剂与烯丙醇的有氧氧化偶联：通过氢迁移构建β-（杂）芳基酮和醛的策略。
Chemistry. 2013 Nov 11;19(46):15462-6. doi: 10.1002/chem.201302962. Epub 2013 Oct 21.
4
Rh-catalyzed C-C cleavage of benzyl/allylic alcohols to produce benzyl/allylic amines or other alcohols by nucleophilic addition of intermediate rhodacycles to aldehydes and imines.铑催化的苄基/烯丙醇的 C-C 裂解，通过中间铑环对醛和亚胺的亲核加成，生成苄基/烯丙基胺或其他醇。
Chemistry. 2012 Dec 7;18(50):16214-25. doi: 10.1002/chem.201201867. Epub 2012 Oct 18.
5
A facile Zr-mediated multicomponent approach to arylated allylic alcohols and its application to the synthesis of highly substituted indenes and spiroindenes.一种简便的锆介导的制备芳基化烯丙醇的多组分方法及其在合成高度取代茚和螺茚中的应用。
Org Biomol Chem. 2008 Jun 21;6(12):2064-70. doi: 10.1039/b804888f. Epub 2008 May 16.
6
Copper-catalyzed dehydrogenative cross-coupling reaction between allylic C-H bonds and α-C-H bonds of ketones or aldehydes.铜催化的烯丙基C-H键与酮或醛的α-C-H键之间的脱氢交叉偶联反应。
Chemistry. 2014 May 26;20(22):6618-21. doi: 10.1002/chem.201402114. Epub 2014 Apr 22.
7
Theoretical investigations on Rh(III)-catalyzed cross-dehydrogenative aryl-aryl coupling via C-H bond activation.铑（III）催化通过C-H键活化的交叉脱氢芳基-芳基偶联反应的理论研究
J Phys Chem A. 2015 Mar 26;119(12):2989-97. doi: 10.1021/jp511564b. Epub 2015 Mar 6.
8
Palladium-Catalyzed Desulfitative Oxidative Coupling between Arenesulfinic Acid Salts and Allylic Alcohols: A Strategy for the Selective Construction of β-Aryl Ketones and Aldehydes.钯催化亚芳基磺酸盐与烯丙醇之间的脱硫氧化偶联反应：一种选择性构建β-芳基酮和醛的策略。
J Org Chem. 2015 Sep 4;80(17):8903-9. doi: 10.1021/acs.joc.5b01463. Epub 2015 Aug 26.
9
Rh(iii)-Catalyzed regioselective C4 alkylation of indoles with allylic alcohols: direct access to β-indolyl ketones.铑(III)催化吲哚与烯丙醇的区域选择性 C4 烷基化反应：β-吲哚基酮的直接合成。
Org Biomol Chem. 2020 Apr 29;18(16):3038-3042. doi: 10.1039/d0ob00396d.
10
RuHCl(CO)(PPh3)3-catalyzed α-alkylation of ketones with primary alcohols.三（三苯基膦）羰基氯化钌（RuHCl(CO)(PPh3)3）催化的酮与伯醇的α-烷基化反应。
Org Lett. 2012 Sep 21;14(18):4703-5. doi: 10.1021/ol302145a. Epub 2012 Aug 29.

引用本文的文献

1
Ru(ii)-catalyzed regioselective oxidative Heck reaction with internal olefins that tolerated strongly coordinating heterocycles.钌（II）催化的与内烯烃的区域选择性氧化Heck反应，该反应能耐受强配位杂环。
Chem Sci. 2024 Nov 19;15(47):20064-20072. doi: 10.1039/d4sc07036d. eCollection 2024 Dec 4.
2
Rhodium(iii) catalyzed olefination and deuteration of tetrahydrocarbazole.铑（III）催化的四氢咔唑的烯基化和氘代反应。
RSC Adv. 2021 Feb 23;11(14):8356-8361. doi: 10.1039/d1ra00236h. eCollection 2021 Feb 17.
3
Rhodium(iii)-catalyzed C-H allylation of indoles with allyl alcohols via β-hydroxide elimination.
铑(III)催化吲哚与烯丙醇的 C-H 烯丙基化反应，通过 β-氢消除。
Org Biomol Chem. 2018 Aug 8;16(31):5691-5698. doi: 10.1039/c8ob01394b.
4
Carboxylate-directed C-H allylation with allyl alcohols or ethers.通过烯丙醇或醚进行羧酸盐导向的C-H烯丙基化反应。
Chem Sci. 2018 May 21;9(23):5289-5294. doi: 10.1039/c8sc01741g. eCollection 2018 Jun 21.
5
Transition-Metal-Catalyzed C-H Bond Addition to Carbonyls, Imines, and Related Polarized π Bonds.过渡金属催化的碳氢键加成到羰基、亚胺及相关极性π键上
Chem Rev. 2017 Jul 12;117(13):9163-9227. doi: 10.1021/acs.chemrev.6b00661. Epub 2016 Dec 12.
6
Convergent Synthesis of Diverse Nitrogen Heterocycles via Rh(III)-Catalyzed C-H Conjugate Addition/Cyclization Reactions.通过 Rh(III)-催化的 C-H 共轭加成/环化反应实现多种氮杂环的汇聚合成。
Org Lett. 2016 Jul 1;18(13):3294-7. doi: 10.1021/acs.orglett.6b01611. Epub 2016 Jun 23.
7
Ru-catalysed C-H arylation of indoles and pyrroles with boronic acids: scope and mechanistic studies.钌催化吲哚和吡咯与硼酸的C-H芳基化反应：范围及机理研究
Chemistry. 2015 Mar 27;21(14):5380-6. doi: 10.1002/chem.201405931. Epub 2015 Feb 17.