School of Chemical and Environmental Engineering, Jiangsu University of Technology, Changzhou 213001, P. R. China.
School of Petrochemical Engineering, Jiangsu Key Laboratory of Advanced Catalytic Materials & Technology, Changzhou University, Changzhou 213164, P. R. China.
Org Biomol Chem. 2020 Apr 29;18(16):3038-3042. doi: 10.1039/d0ob00396d.
A Rh(iii)-catalyzed and weak coordination carbonyl guided direct C4 alkylation of indoles with allylic alcohols was developed with excellent regioselectivity. This reaction was conducted under mild conditions, leading to a variety of β-indolyl ketones with good functional group tolerance in moderate to good yields.
发展了一种 Rh(iii)催化的、弱配位羰基导向的吲哚与烯丙醇的直接 C4 烷基化反应，具有优异的区域选择性。该反应在温和条件下进行，导致各种β-吲哚基酮以中等至良好的产率具有良好的官能团耐受性。
