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经股动脉和经心尖经导管主动脉瓣植入术中紧急心脏手术:单中心 411 例患者的发生率、原因、处理方法和结局。

Emergency cardiac surgery during transfemoral and transapical transcatheter aortic valve implantation: incidence, reasons, management, and outcome of 411 patients from a single center.

机构信息

Department of Cardiology, Cardiovascular Center Bad Neustadt, Bad Neustadt a.d., Saale, Germany.

出版信息

Catheter Cardiovasc Interv. 2013 Nov 1;82(5):E726-33. doi: 10.1002/ccd.25049. Epub 2013 Jul 19.

DOI:10.1002/ccd.25049
PMID:23765631
Abstract

OBJECTIVES AND BACKGROUND

Transcatheter aortic valve implantation (TAVI) is increasingly performed in high-risk patients with severe aortic valve stenosis. Incidence and impact of emergency cardiac surgery (ECS) during TAVI is unclear.

METHODS AND RESULTS

Two-hundred twenty one transapical (TA) and 190 transfemoral (TF) TAVIs were performed at our hospital between 01/2009 and 12/2012. Twenty patients (4.9%) required ECS, more frequently in the TF- (n = 11; 5.8%) than in the TA-group (n = 9; 4.1%; P = 0.017). ECS-cases were evenly distributed throughout the 4 years. Baseline characteristics of the ECS-patients were not different from the non-ECS-patients. Reasons were acute cardiac failure, coronary obstruction, annular rupture, valve migration, right- and left-ventricular perforation, severe paravalvular leakage, aortic dissection, and mitral valve damage. Surgical intervention consisted of peripheral CPB, switch to TA, thoracotomy and suture of perforated cardiac chambers and conventional aortic valve replacement with concomitant repair of associated cardiovascular injury. Thirty-day mortality was 35.0%, and 55.0% could be salvaged to hospital discharge. Kaplan-Meier 1-year survival curves were significantly impaired for patients requiring ECS (TF: P < 0.0001, HR 8.716; TA: P = 0.013, HR 2.813).

CONCLUSIONS

Life-threatening complications requiring bail-out ECS occur in a substantial proportion during TAVI. ECS dramatically affects early and late outcome after TAVI. Under optimal conditions more than half of the ECS-patients can be salvaged. With the current technology of THV-systems ECS should be an integral part of the logistic conditions surrounding TAVI and is far from being futile in this patient population.

摘要

目的和背景

经导管主动脉瓣植入术(TAVI)越来越多地应用于严重主动脉瓣狭窄的高危患者。在 TAVI 期间紧急心脏手术(ECS)的发生率和影响尚不清楚。

方法和结果

我院于 2009 年 1 月至 2012 年 12 月期间共进行了 221 例经心尖(TA)和 190 例经股动脉(TF)TAVI。20 例(4.9%)患者需要 ECS,TF 组(n=11;5.8%)比 TA 组(n=9;4.1%)更常见(P=0.017)。ECS 病例在 4 年中均匀分布。ECS 患者的基线特征与非 ECS 患者无差异。原因包括急性心功能衰竭、冠状动脉阻塞、瓣环破裂、瓣膜移位、左右心室穿孔、严重瓣周漏、主动脉夹层和二尖瓣损伤。手术干预包括外周 CPB、切换至 TA、开胸和缝合穿孔的心脏腔室以及常规主动脉瓣置换,同时修复相关心血管损伤。30 天死亡率为 35.0%,55.0%可存活至出院。需要 ECS 的患者的 Kaplan-Meier 1 年生存率曲线明显受损(TF:P<0.0001,HR 8.716;TA:P=0.013,HR 2.813)。

结论

在 TAVI 过程中,需要救生 ECS 的危及生命的并发症发生率相当高。ECS 显著影响 TAVI 后的早期和晚期结果。在最佳条件下,超过一半的 ECS 患者可以获救。在当前 THV 系统技术的条件下,ECS 应成为 TAVI 周围后勤条件的一个组成部分,在该患者人群中并非没有意义。

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