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Dysregulated CD1 profile in myeloid dendritic cells in CVID is normalized by IVIg treatment.在常见变异型免疫缺陷病（CVID）中，髓样树突状细胞中失调的CD1谱通过静脉注射免疫球蛋白（IVIg）治疗得以正常化。
Blood. 2013 Jun 13;121(24):4963-4. doi: 10.1182/blood-2013-04-499442.
2
Intravenous immunoglobulin (IVIG) efficiency in women with common variable immunodeficiency (CVID) decreases significantly during pregnancy.静脉注射免疫球蛋白（IVIG）对患有常见可变免疫缺陷（CVID）的女性的疗效在孕期会显著降低。
J Matern Fetal Neonatal Med. 2019 Sep;32(18):3092-3096. doi: 10.1080/14767058.2018.1455824. Epub 2018 Apr 3.
3
Potential Anti-Tumor Activity of Intravenous and Subcutaneous Immunoglobulin.静脉注射和皮下注射免疫球蛋白的潜在抗肿瘤活性
Isr Med Assoc J. 2018 Dec;20(12):782-783.
4
35-Year-Old Man With Episodic Fever and Cough.35岁男性，伴有间歇性发热和咳嗽
Mayo Clin Proc. 2018 Dec;93(12):1848-1852. doi: 10.1016/j.mayocp.2018.03.031. Epub 2018 Nov 7.
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In vivo modulation of the expressions of Fas and CD25 by intravenous immunoglobulin in common variable immunodeficiency.静脉注射免疫球蛋白对普通变异性免疫缺陷病中 Fas 和 CD25 表达的体内调节。
Clin Exp Med. 2010 Mar;10(1):27-31. doi: 10.1007/s10238-009-0061-1.
6
A pilot study of equal doses of 10% IGIV given intravenously or subcutaneously.一项关于静脉注射或皮下注射等量10%静脉注射免疫球蛋白的试点研究。
J Allergy Clin Immunol. 2009 Oct;124(4):854-6. doi: 10.1016/j.jaci.2009.07.051. Epub 2009 Sep 19.
7
Practical aspects of immunoglobulin replacement.免疫球蛋白替代疗法的实际应用
Ann Allergy Asthma Immunol. 2017 Oct;119(4):299-303. doi: 10.1016/j.anai.2017.07.020.
8
A double-blind, placebo-controlled, crossover therapy study with natural human IL-2 (nhuIL-2) in combination with regular intravenous gammaglobulin (IVIG) infusions in 10 patients with common variable immunodeficiency (CVID).一项针对10名常见可变免疫缺陷（CVID）患者的双盲、安慰剂对照、交叉治疗研究，该研究使用天然人白细胞介素-2（nhuIL-2）联合常规静脉注射丙种球蛋白（IVIG）。
Clin Exp Immunol. 1997 Nov;110(2):167-73. doi: 10.1111/j.1365-2249.1997.tb08313.x.
9
Common variable immunodeficiency patients display elevated plasma levels of granulocyte activation markers elastase and myeloperoxidase.普通变异性免疫缺陷患者的血浆中粒细胞活化标志物弹性蛋白酶和髓过氧化物酶水平升高。
Int J Immunopathol Pharmacol. 2019 Jan-Dec;33:2058738419843381. doi: 10.1177/2058738419843381.
10
Elevated frequency of CD1c+ myeloid dendritic cells in the peripheral blood mononuclear cells of simian/human immunodeficiency virus (SHIV) and simian immunodeficiency virus (SIV) repeatedly infected Chinese rhesus macaques.外周血单个核细胞中 CD1c+ 髓样树突状细胞在感染恒河猴猴免疫缺陷病毒（SHIV）和猴免疫缺陷病毒（SIV）中的频率升高。
Cell Immunol. 2011;271(1):36-43. doi: 10.1016/j.cellimm.2011.05.017. Epub 2011 Jun 6.

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Modulatory Effects of Antibody Replacement Therapy to Innate and Adaptive Immune Cells.抗体替代疗法对固有免疫细胞和适应性免疫细胞的调节作用。
Front Immunol. 2017 Jun 16;8:697. doi: 10.3389/fimmu.2017.00697. eCollection 2017.
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Vitamin D treatment modulates immune activation in cystic fibrosis.维生素D治疗可调节囊性纤维化中的免疫激活。
Clin Exp Immunol. 2017 Sep;189(3):359-371. doi: 10.1111/cei.12984. Epub 2017 May 24.
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Innate Invariant NKT Cell Recognition of HIV-1-Infected Dendritic Cells Is an Early Detection Mechanism Targeted by Viral Immune Evasion.天然不变自然杀伤T细胞对HIV-1感染的树突状细胞的识别是病毒免疫逃逸所针对的一种早期检测机制。
J Immunol. 2016 Sep 1;197(5):1843-51. doi: 10.4049/jimmunol.1600556. Epub 2016 Aug 1.
4
Inversion of the Vδ1 to Vδ2 γδ T cell ratio in CVID is not restored by IVIg and is associated with immune activation and exhaustion.在常见变异型免疫缺陷病（CVID）中，Vδ1至Vδ2 γδ T细胞比例的倒置不能通过静脉注射免疫球蛋白（IVIg）恢复，且与免疫激活和耗竭相关。
Medicine (Baltimore). 2016 Jul;95(30):e4304. doi: 10.1097/MD.0000000000004304.
5
Expression of CD1a and Type-1 Polarization Are Dissociated in Human Monocyte-Derived Dendritic Cells.人单核细胞衍生树突状细胞中CD1a的表达与1型极化相互分离。
PLoS One. 2015 Oct 13;10(10):e0140432. doi: 10.1371/journal.pone.0140432. eCollection 2015.
6
Mechanisms of action of Ig preparations: immunomodulatory and anti-inflammatory effects.免疫球蛋白制剂的作用机制：免疫调节和抗炎作用。
Front Immunol. 2015 Jan 12;5:690. doi: 10.3389/fimmu.2014.00690. eCollection 2014.
7
Persistent Immune Activation in CVID and the Role of IVIg in Its Suppression.普通变异型免疫缺陷病中的持续免疫激活及静脉注射免疫球蛋白在抑制该激活中的作用
Front Immunol. 2014 Dec 16;5:637. doi: 10.3389/fimmu.2014.00637. eCollection 2014.
8
Intravenous immunoglobulin replacement therapy in common variable immunodeficiency induces B cell depletion through differentiation into apoptosis-prone CD21(low) B cells.普通可变免疫缺陷中的静脉注射免疫球蛋白替代疗法通过分化为易于凋亡的CD21（低）B细胞诱导B细胞耗竭。
Immunol Res. 2014 Dec;60(2-3):330-8. doi: 10.1007/s12026-014-8599-8.
9
Exhaustion of bacteria-specific CD4 T cells and microbial translocation in common variable immunodeficiency disorders.常见可变免疫缺陷病中细菌特异性CD4 T细胞耗竭与微生物易位
J Exp Med. 2014 Sep 22;211(10):2033-45. doi: 10.1084/jem.20140039. Epub 2014 Sep 15.
10
Defective functions of polymorphonuclear neutrophils in patients with common variable immunodeficiency.常见可变免疫缺陷患者多形核中性粒细胞的功能缺陷
Immunol Res. 2014 Oct;60(1):69-76. doi: 10.1007/s12026-014-8555-7.

本文引用的文献

1
Invariant natural killer T cells: an innate activation scheme linked to diverse effector functions.不变自然杀伤 T 细胞：与多种效应功能相关的先天激活方案。
Nat Rev Immunol. 2013 Feb;13(2):101-17. doi: 10.1038/nri3369. Epub 2013 Jan 21.
2
Novel insights into lipid antigen presentation.脂质抗原呈递的新见解。
Trends Immunol. 2012 Mar;33(3):103-11. doi: 10.1016/j.it.2012.01.005. Epub 2012 Feb 16.
3
Common variable immunodeficiency (CVID): exploring the multiple dimensions of a heterogeneous disease.常见可变免疫缺陷（CVID）：探索一种异质性疾病的多个维度。
Ann N Y Acad Sci. 2012 Feb;1250:41-9. doi: 10.1111/j.1749-6632.2011.06377.x. Epub 2012 Feb 2.
4
Common variable immunodeficiency: a new look at an old disease.普通可变免疫缺陷：对一种旧疾病的新审视。
Lancet. 2008 Aug 9;372(9637):489-502. doi: 10.1016/S0140-6736(08)61199-X.
5
IgG regulates the CD1 expression profile and lipid antigen-presenting function in human dendritic cells via FcgammaRIIa.免疫球蛋白G通过FcγRIIa调节人类树突状细胞中的CD1表达谱和脂质抗原呈递功能。
Blood. 2008 May 15;111(10):5037-46. doi: 10.1182/blood-2007-07-099549. Epub 2008 Mar 12.
6
The surprising diversity of lipid antigens for CD1-restricted T cells.CD1 限制性 T 细胞的脂质抗原具有惊人的多样性。
Adv Immunol. 2006;89:87-139. doi: 10.1016/S0065-2776(05)89003-0.
7
Langerhans cells - dendritic cells of the epidermis.朗格汉斯细胞——表皮的树突状细胞。
APMIS. 2003 Jul-Aug;111(7-8):725-40. doi: 10.1034/j.1600-0463.2003.11107805.x.
8
Characterization of human blood dendritic cell subsets.人类血液树突状细胞亚群的特征分析。
Blood. 2002 Dec 15;100(13):4512-20. doi: 10.1182/blood-2001-11-0097. Epub 2002 Aug 15.
9
BDCA-2, BDCA-3, and BDCA-4: three markers for distinct subsets of dendritic cells in human peripheral blood.BDCA-2、BDCA-3和BDCA-4：人类外周血中不同树突状细胞亚群的三种标志物。
J Immunol. 2000 Dec 1;165(11):6037-46. doi: 10.4049/jimmunol.165.11.6037.

Dysregulated CD1 profile in myeloid dendritic cells in CVID is normalized by IVIg treatment.

作者信息

Paquin-Proulx Dominic, Santos Bianca A N, Carvalho Karina I, Toledo-Barros Myrthes, Oliveira Ana Karolina Barreto de, Kokron Cristina M, Kalil Jorge, Moll Markus, Kallas Esper G, Sandberg Johan K

机构信息

Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.

出版信息

Blood. 2013 Jun 13;121(24):4963-4. doi: 10.1182/blood-2013-04-499442.

DOI:10.1182/blood-2013-04-499442
PMID:23766460
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3682345/
Abstract
摘要