疾病、癌症、药物及数据库的可变剪接
Alternative splicing for diseases, cancers, drugs, and databases.
作者信息
Tang Jen-Yang, Lee Jin-Ching, Hou Ming-Feng, Wang Chun-Lin, Chen Chien-Chi, Huang Hurng-Wern, Chang Hsueh-Wei
机构信息
Department of Radiation Oncology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
出版信息
ScientificWorldJournal. 2013 May 22;2013:703568. doi: 10.1155/2013/703568. Print 2013.
Abstract
Alternative splicing is a major diversification mechanism in the human transcriptome and proteome. Several diseases, including cancers, have been associated with dysregulation of alternative splicing. Thus, correcting alternative splicing may restore normal cell physiology in patients with these diseases. This paper summarizes several alternative splicing-related diseases, including cancers and their target genes. Since new cancer drugs often target spliceosomes, several clinical drugs and natural products or their synthesized derivatives were analyzed to determine their effects on alternative splicing. Other agents known to have modulating effects on alternative splicing during therapeutic treatment of cancer are also discussed. Several commonly used bioinformatics resources are also summarized.
摘要
可变剪接是人类转录组和蛋白质组中的一种主要多样化机制。包括癌症在内的多种疾病都与可变剪接失调有关。因此，纠正可变剪接可能会恢复这些疾病患者的正常细胞生理功能。本文总结了几种与可变剪接相关的疾病，包括癌症及其靶基因。由于新型抗癌药物通常靶向剪接体，因此对几种临床药物、天然产物或其合成衍生物进行了分析，以确定它们对可变剪接的影响。还讨论了在癌症治疗过程中已知对可变剪接有调节作用的其他药物。同时也总结了几种常用的生物信息学资源。
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