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使用树状金属催化剂在透析袋中进行水相还原胺化反应。

Aqueous reductive amination using a dendritic metal catalyst in a dialysis bag.

机构信息

Radboud University Nijmegen, Institute for Molecules and Materials, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands.

出版信息

Beilstein J Org Chem. 2013 May 17;9:960-5. doi: 10.3762/bjoc.9.110. Print 2013.

DOI:10.3762/bjoc.9.110
PMID:23766812
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3678615/
Abstract

Water-soluble dendritic iridium catalysts were synthesized by attaching a reactive metal complex to DAB-Am dendrimers via an adapted asymmetric bipyridine ligand. These dendritic catalysts were applied in the aqueous reductive amination of valine while contained in a dialysis bag. Comparable conversions were observed as for the noncompartmentalized counterparts, albeit with somewhat longer reaction times. These results clearly show that the encapsulated catalyst system is suitable to successfully drive a complex reaction mixture with various equilibrium reactions to completion.

摘要

通过将反应性金属配合物通过经改良的不对称联吡啶配体连接到 DAB-Am 树枝状聚合物上来合成水溶性树枝状铱催化剂。这些树枝状催化剂被应用于包含在透析袋中的缬氨酸的水相还原胺化。尽管反应时间稍长，但观察到与非分隔对应物相当的转化率。这些结果清楚地表明，封装的催化剂体系适合成功地驱动具有各种平衡反应的复杂反应混合物至完成。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcb3/3678615/8822a69260c3/Beilstein_J_Org_Chem-09-960-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcb3/3678615/cd6d8482309b/Beilstein_J_Org_Chem-09-960-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcb3/3678615/72d49efc0436/Beilstein_J_Org_Chem-09-960-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcb3/3678615/f5f72246a690/Beilstein_J_Org_Chem-09-960-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcb3/3678615/a23b39264598/Beilstein_J_Org_Chem-09-960-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcb3/3678615/e7cff61a796e/Beilstein_J_Org_Chem-09-960-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcb3/3678615/8322db6c90de/Beilstein_J_Org_Chem-09-960-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcb3/3678615/89739f53d8e3/Beilstein_J_Org_Chem-09-960-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcb3/3678615/2e00941f91ce/Beilstein_J_Org_Chem-09-960-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcb3/3678615/8822a69260c3/Beilstein_J_Org_Chem-09-960-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcb3/3678615/cd6d8482309b/Beilstein_J_Org_Chem-09-960-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcb3/3678615/72d49efc0436/Beilstein_J_Org_Chem-09-960-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcb3/3678615/f5f72246a690/Beilstein_J_Org_Chem-09-960-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcb3/3678615/a23b39264598/Beilstein_J_Org_Chem-09-960-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcb3/3678615/e7cff61a796e/Beilstein_J_Org_Chem-09-960-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcb3/3678615/8322db6c90de/Beilstein_J_Org_Chem-09-960-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcb3/3678615/89739f53d8e3/Beilstein_J_Org_Chem-09-960-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcb3/3678615/2e00941f91ce/Beilstein_J_Org_Chem-09-960-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcb3/3678615/8822a69260c3/Beilstein_J_Org_Chem-09-960-g006.jpg

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