细胞蛋白质与形态各异的小分子纳米聚集体之间的相互作用。
Interactions between cellular proteins and morphologically different nanoscale aggregates of small molecules.
作者信息
Kuang Yi, Yuan Dan, Zhang Ye, Kao Anita, Du Xuewen, Xu Bing
机构信息
Department of Chemistry, Brandeis University, 415 South St., Waltham, MA 02454, USA. ; Tel: 781-736-5201.
出版信息
RSC Adv. 2013 Jun 7;3(21):7704-7707. doi: 10.1039/C3RA41523F.
Abstract
Depending on the methods of preparation, amphiphilic small molecules aggregate to form nanostructures with different morphologies that interact with cytosol proteins in a drastically different manner, thus illustrating the first example of morphological dependent protein binding of nanoscale molecular aggregates.
摘要
根据制备方法的不同，两亲性小分子会聚集形成具有不同形态的纳米结构，这些纳米结构与胞质溶胶蛋白的相互作用方式截然不同，从而例证了纳米级分子聚集体形态依赖性蛋白结合的首个实例。
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