Hernán Martínez José, Torres Oberto, Mangual Michelle M, Palermo Coromoto, Figueroa Carlos, Santiago Mónica, Miranda María de Lourdes, González Eva
Endocrinology Department, San Juan City Hospital, San Juan, Puerto Rico.
Bol Asoc Med P R. 2013;105(1):57-61.
Hashimoto's encephalopathy (HE) is a rarely recognized neurocognitive syndrome that is associated with thyroid autoimmunity. It is more common in women. HE is diagnosed when patients present with nonspecific neurological symptoms associated to elevated titers of antithyroid antibodies and normal or abnormal thyroid function tests. Other neurologic disorders must be ruled out before diagnosis can be established. HE is associated to nonspecific EEG abnormalities as well as elevated cerebrospinal fluid proteins and nonspecific white matter changes. The pathophysiology of HE is unknown but an autoimmune etiology is strongly supported. HE responds to corticosteroids and immunosuppressive therapy, further supporting an autoimmune etiology. A high index of clinical suspicion must be present in order to promptly recognize and treat this disease.
桥本脑病（HE）是一种鲜为人知的神经认知综合征，与甲状腺自身免疫有关。多见于女性。当患者出现与抗甲状腺抗体滴度升高相关的非特异性神经症状，且甲状腺功能检查正常或异常时，可诊断为HE。在确诊之前，必须排除其他神经系统疾病。HE与非特异性脑电图异常、脑脊液蛋白升高及非特异性白质改变有关。HE的病理生理学尚不清楚，但强烈支持自身免疫病因。HE对皮质类固醇和免疫抑制治疗有反应，进一步支持自身免疫病因。必须高度怀疑，以便及时识别和治疗这种疾病。
