Nachbauer Wolfgang, Eigentler Andreas, Boesch Sylvia
Department of Neurology, Medical University Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria.
J Neurol. 2015 May;262(5):1385-93. doi: 10.1007/s00415-015-7685-8. Epub 2015 Mar 26.
Acquired ataxias represent a large group of disorders defined by the common clinical feature of ataxia and the absence of a clear genetic basis for it. Based on the aetiology, the group can be subdivided into autoimmune, toxic, infectious and vitamin deficiency causes. Cerebellar ataxia may occur as an isolated syndrome in this spectrum of disorders but is often accompanied by additional neurological manifestations. Clinical work-up is challenging and mainly includes biochemical analyses, whereas imaging is of minor significance. Diagnosis is essential as many of these disorders represent potential treatable conditions and early therapy may prevent progressive cerebellar ataxia. The clinical findings, the implications for diagnosis and management of this heterogeneous group of disorders are discussed in this review.
获得性共济失调是一大类疾病，其共同临床特征为共济失调且无明确的遗传基础。根据病因，该类疾病可细分为自身免疫性、中毒性、感染性和维生素缺乏性病因。在这一系列疾病中，小脑性共济失调可能作为一种孤立综合征出现，但常伴有其他神经系统表现。临床检查具有挑战性，主要包括生化分析，而影像学检查意义较小。由于这些疾病中的许多都代表了潜在的可治疗情况，早期治疗可能预防进行性小脑性共济失调，因此诊断至关重要。本综述讨论了这一异质性疾病组的临床发现、诊断及管理意义。
