Cechurová D, Lacigová S, Zourek M, Gruberová J, Haladová I, Tomešová J, Rušavý Z
Interni Kliniky Lekarske Fakulty UK a FN Plzen.
Vnitr Lek. 2013 May;59(5):412-5.
Spinal column infection (vertebral osteomyelitis, discitis, epidural empyema/ abscess) is a rare condition, albeit its incidence has been increasing in recent years. Staphylococcus aureus is the most frequent pathogen. The routes of infection are predominantly hematogenous. Any delay in making correct diagnosis increases risk of adverse outcome of the patient. The authors present 3 case reports of patients with diabetic foot syndrome, who were diagnosed with spondylodicitis in the period of 2009- 2012, two patients had associated epidural empyema. Apart of a chronic neuropathic foot wound, the patients reported severe or deteriorated dorsal pain (2 in the lumbal region, one in thoracic spine), had no new neurologic lesion in the beginning, some had fever, but all had high laboratory parameters of inflammation that did not correlate with local finding on the foot. Methicillin sensitive Staphylococcus aureus cultured from the foot defect in all cases, in two patients from blood cultures and from epidural empyema. They were patients with recurrent local infectious complications of diabetic foot ulcers. Two patients had a concomitant diabetic nephropathy, classified into stages 3- 4/ 5 according to K/ DOQI. Glycemic control (Type 1, Type 2 and secondary DM) ranged from excellent to unsatisfactory (HbA1c 43- 100 mmol/ mol). Apart of patient history and clinical examination, the magnetic resonance imaging of the spine was essential for the diagnosis of spondylodiscitis, or epidural empyema. The treatment was founded on longterm (initially parenteral) antibiotic treatment, bed rest, then mobilization with orthosis. Neurosurgical procedure was necessary in the patients with epidural empyema. All patients were mobile following a varied time period of convalescence and rehabilitation.
Dorsal pain and degenerative changes of the spinal column belong to common findings in our population. When searching for the origin of an infection in patients with elevated inflammatory parameters (inadequate finding for a diabetic ulcer), the history of dorsal pain suddenly becomes the fundamental clue for diagnosis of spondylodiscitis with or without epidural empyema.
脊柱感染(椎体骨髓炎、椎间盘炎、硬膜外脓肿)是一种罕见疾病,尽管近年来其发病率一直在上升。金黄色葡萄球菌是最常见的病原体。感染途径主要是血行性的。正确诊断的任何延迟都会增加患者出现不良后果的风险。作者介绍了3例糖尿病足综合征患者的病例报告,这些患者在2009年至2012年期间被诊断为脊椎炎,其中2例患者伴有硬膜外脓肿。除了慢性神经性足部伤口外,患者报告有严重或加重的背痛(2例在腰部区域,1例在胸椎),起初没有新的神经病变,部分患者有发热,但所有患者炎症实验室指标均较高,且与足部局部表现不相关。所有病例足部缺损处培养出对甲氧西林敏感的金黄色葡萄球菌,2例患者血培养及硬膜外脓肿培养也为该菌。他们是糖尿病足溃疡反复出现局部感染并发症的患者。2例患者伴有糖尿病肾病,根据K/DOQI分类为3 - 4/5期。血糖控制(1型、2型和继发性糖尿病)范围从良好到不满意(糖化血红蛋白43 - 100 mmol/mol)。除了患者病史和临床检查外,脊柱磁共振成像对于脊椎椎间盘炎或硬膜外脓肿的诊断至关重要。治疗基于长期(最初为肠外)抗生素治疗、卧床休息,然后使用矫形器进行活动。有硬膜外脓肿的患者需要进行神经外科手术。所有患者在经过不同时间的康复和恢复后都能够活动。
背痛和脊柱退行性改变是我们人群中的常见表现。当在炎症指标升高的患者(糖尿病溃疡表现不充分)中寻找感染源时,背痛病史突然成为诊断有无硬膜外脓肿的脊椎椎间盘炎的关键线索。