Folkhälsan Research Centre, Helsinki, Finland.
Ann Med. 2013 Sep;45(5-6):430-7. doi: 10.3109/07853890.2013.801275. Epub 2013 Jun 14.
Prenatal and childhood growth influence the risk of developing the metabolic syndrome and type 2 diabetes. Both conditions are associated with non-alcoholic fatty liver disease (NAFLD). Our aim was to explore the associations between early growth and adult NAFLD.
We studied 1587 individuals from the Helsinki Birth Cohort Study (HBCS) born 1934-44 for whom birth, childhood, and adult clinical data were available. NAFLD was defined using the NAFLD liver fat score and equation. The score was converted into a dichotomous variable, with outcomes defined as either a positive or negative score. The equation predicts liver fat percentage.
A positive score was found in 43% of men and 22.5% of women. Several measurements of birth and childhood body size were negatively associated with both NAFLD outcomes after adjustment for adult BMI. Those from the smallest BMI tertile at age 2 who were obese in adulthood had an OR of 18.5 for a positive score compared to those from the same group who were normal weight in adulthood.
A larger childhood body size was negatively associated with NAFLD outcomes. Individuals who are small during early childhood and obese as adults seem to be at the highest risk of developing NAFLD.
产前和儿童时期的生长发育会影响代谢综合征和 2 型糖尿病的发病风险。这两种疾病都与非酒精性脂肪性肝病（NAFLD）有关。我们的目的是探讨早期生长与成人非酒精性脂肪性肝病之间的关系。
我们对 1934 年至 1944 年出生于赫尔辛基出生队列研究（HBCS）的 1587 名个体进行了研究，这些个体的出生、儿童期和成年期临床数据均可用。使用 NAFLD 肝脂肪评分和方程来定义 NAFLD。将评分转换为二分类变量，结果定义为阳性或阴性评分。该方程预测肝脂肪百分比。
男性中有 43%，女性中有 22.5%存在阳性评分。在调整成年 BMI 后，出生和儿童时期的多种身体大小测量值与两种 NAFLD 结果均呈负相关。在成年时肥胖的 2 岁时处于 BMI 最小三分位数的个体，其阳性评分的 OR 为 18.5，而在成年时体重正常的同组个体的 OR 为 1。
儿童时期较大的体型与 NAFLD 结果呈负相关。在儿童早期体型较小且成年后肥胖的个体似乎患 NAFLD 的风险最高。
