* Department of Biological Science and Technology.
Med Mycol. 2013 Nov;51(8):880-3. doi: 10.3109/13693786.2013.800240. Epub 2013 Jun 14.
Among 32 Trichosporon asahii isolates collected in four rounds of the Taiwan Surveillance of Antimicrobial Resistance of Yeasts (TSARY) studies, conducted in 1999, 2002, 2006, and 2010, five different intergenic spacer 1 (IGS1) genotypes were detected. Genotype 1 was the most common (43.8%), followed by genotypes 3 (28.1%), 7 (12.5%), 5 (9.4%), and 4 (6.3%). Interestingly, genotype 7 was more prevalent in Taiwan than in other areas (P = 0.01); while we did not find a significant association between IGS1 genotype and susceptibility to antifungal drugs, we did note that the majority of isolates of T. asahii were susceptible to both fluconazole and voriconazole, consistent with previous reports. A higher proportion of isolates (P = 0.05) collected in 2010 (4/12, 33.3%) had high amphotericin B MICs (≥ 2 mg/l) than those collected in the previous three TSARYs (1/21, 5%). Hence, the new data of genotypes and drug susceptibilities in the present study may contribute to the epidemiology of T. asahii.
在台湾念珠菌抗药性监测研究（TSARY）于 1999 年、2002 年、2006 年和 2010 年进行的四轮研究中收集的 32 株新生隐球菌分离株中，检测到五种不同的基因间间隔 1（IGS1）基因型。基因型 1 最为常见（43.8%），其次是基因型 3（28.1%）、7（12.5%）、5（9.4%）和 4（6.3%）。有趣的是，基因型 7在台湾比在其他地区更为普遍（P=0.01）；虽然我们没有发现 IGS1 基因型与抗真菌药物敏感性之间存在显著关联，但我们确实注意到，大多数新生隐球菌分离株对氟康唑和伏立康唑均敏感，这与之前的报告一致。2010 年采集的分离株（4/12，33.3%）中，有较高比例的分离株对两性霉素 B 的 MIC 值较高（≥2mg/L）（P=0.05），高于之前三轮 TSARY 研究（1/21，5%）中采集的分离株。因此，本研究中基因型和药物敏感性的新数据可能有助于新生隐球菌的流行病学研究。
