Departament de Bioquímica i Biotecnologia, Universitat Rovira i Virgili, C. Marcel·lí Domingo, s/n, 43007 Tarragona, Spain.
Food Chem. 2013 Nov 1;141(1):160-6. doi: 10.1016/j.foodchem.2013.02.104. Epub 2013 Mar 7.
Visceral and subcutaneous adipose depots have different metabolic roles that may be involved in the development of obesity-related pathologies. Procyanidins have beneficial effects on insulin resistance, and they target adipose tissue. We analyse whether procyanidins exert different effects, depending on the adipose tissue depot, and whether these effects show a relation to the amount of phenolic compound in the tissue. We studied the effects of a grape seed procyanidin extract (GSPE) treatment at the transcriptional level on genes expressed differentially between mesenteric and subcutaneous adipose tissue depots and genes previously shown to be targets of procyanidins. Procyanidins target mesenteric adipose tissue in Wistar lean rats but subcutaneous adipose tissue in Zucker obese rats. Non-modified structures also accumulated, preferentially in the same respective tissues that were responsive to GSPE. Thus, procyanidins target and accumulate differently in mesenteric and subcutaneous adipose tissue depots, depending on the metabolic condition of the animal model.
内脏和皮下脂肪组织具有不同的代谢作用，可能与肥胖相关病理的发生有关。原花青素对胰岛素抵抗具有有益作用，并且可以靶向脂肪组织。我们分析原花青素是否会根据脂肪组织的位置产生不同的作用，以及这些作用是否与组织中酚类化合物的含量有关。我们研究了葡萄籽原花青素提取物（GSPE）在转录水平上对肠系膜和皮下脂肪组织之间差异表达的基因以及先前被证明是原花青素靶标的基因的影响。原花青素靶向 Wistar 瘦大鼠的肠系膜脂肪组织，但靶向 Zucker 肥胖大鼠的皮下脂肪组织。非修饰结构也会积累，主要是在对 GSPE 有反应的相同组织中。因此，原花青素在肠系膜和皮下脂肪组织中的靶向和积累方式因动物模型的代谢状态而异。
