Department of Microbiology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
Cell Host Microbe. 2013 Jun 12;13(6):629-31. doi: 10.1016/j.chom.2013.05.015.
Osteomyelitis is a debilitating bone infection often caused by the bacterial pathogen Staphylococcus aureus. In this issue, Cassat et al. (2013) develop a high-resolution microcomputed tomography (microCT) method to visualize bone remodeling during S. aureus infection and discover that the metalloprotease aureolysin plays a critical role in modulating osteomyelitis pathogenesis.
骨髓炎是一种使人虚弱的骨感染，通常由细菌病原体金黄色葡萄球菌引起。在本期中，Cassat 等人（2013）开发了一种高分辨率的微计算机断层扫描（microCT）方法来可视化金黄色葡萄球菌感染过程中的骨重塑，并发现金属蛋白酶 aureolysin 在调节骨髓炎发病机制方面起着关键作用。
