金黄色葡萄球菌骨髓炎：病入骨髓。
Staphylococcus aureus osteomyelitis: bad to the bone.
机构信息
Department of Microbiology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
出版信息
Cell Host Microbe. 2013 Jun 12;13(6):629-31. doi: 10.1016/j.chom.2013.05.015.
Abstract
Osteomyelitis is a debilitating bone infection often caused by the bacterial pathogen Staphylococcus aureus. In this issue, Cassat et al. (2013) develop a high-resolution microcomputed tomography (microCT) method to visualize bone remodeling during S. aureus infection and discover that the metalloprotease aureolysin plays a critical role in modulating osteomyelitis pathogenesis.
摘要
骨髓炎是一种使人虚弱的骨感染，通常由细菌病原体金黄色葡萄球菌引起。在本期中，Cassat 等人（2013）开发了一种高分辨率的微计算机断层扫描（microCT）方法来可视化金黄色葡萄球菌感染过程中的骨重塑，并发现金属蛋白酶 aureolysin 在调节骨髓炎发病机制方面起着关键作用。
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3
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