Reproductive Center of the First Affiliated Hospital of Sun Yat-sen University, Number 58, Zhongshan Road, Guangzhou 510080, China.
Asian Pac J Trop Med. 2013 Jul;6(7):578-82. doi: 10.1016/S1995-7645(13)60100-5.
To explore the effects of different M II stage oocytes zona pellucida birefringence on pregnancy outcome.
A total of 46 couples with infertile which induced by single cause received in-vitro fertilization treatment were analyzed retrospectively, and randomly divided into the high zona birefringence (HZB)/HZB group, HZB/low zona birefringence (LZB) group and LZB/LZB group according to different oocytes zona pellucida birefringence. Intracytoplasmic sperm injection outcome was analyzed and compared.
The proportion of HZB oocytes, implantation rate and the pregnancy rate were decreased in three groups (HZB/HZB group>HZB/LZB group>LZB/LZB group) (P<0.05). But there was no significantly different between the number of oocytes and fertilization rate of these groups (P>0.05). Logistic regression analysis showed that factors affect M II stage oocytes zona pellucida birefringence were age, basal FSH level and the LH level on the day of HCG injection. Age and FSH levels were negatively correlated with the single oocyte zona pellucida birefringence; While the LH level on the day of hCG injection was positively correlated with the single oocyte zona pellucida birefringence.
The primary influence factors on M II stage oocytes zona pellucida are age, basal FSH level and the LH level on the day of hCG injection. The birefringence value of zona pellucida can affect the pregnancy outcome.
探讨不同 M II 期卵母细胞透明带双折射对妊娠结局的影响。
回顾性分析 46 对因单一原因导致不孕接受体外受精治疗的夫妇，并随机分为高透明带双折射（HZB）/HZB 组、HZB/低透明带双折射（LZB）组和 LZB/LZB 组，根据不同的卵母细胞透明带双折射进行分组。分析比较卵胞浆内单精子注射结局。
三组 HZB 卵母细胞比例、着床率和妊娠率均降低（HZB/HZB 组>HZB/LZB 组>LZB/LZB 组）（P<0.05）。但三组间卵母细胞数和受精率差异无统计学意义（P>0.05）。Logistic 回归分析显示，影响 M II 期卵母细胞透明带双折射的因素有年龄、基础 FSH 水平和 hCG 注射日 LH 水平。年龄和 FSH 水平与单个卵母细胞透明带双折射呈负相关；而 hCG 注射日 LH 水平与单个卵母细胞透明带双折射呈正相关。
影响 M II 期卵母细胞透明带的主要因素是年龄、基础 FSH 水平和 hCG 注射日 LH 水平。透明带双折射值会影响妊娠结局。
