Department of Human Anatomy, Medical University of Bialystok, Poland.
Leuk Res. 2013 Sep;37(9):1089-93. doi: 10.1016/j.leukres.2013.05.014. Epub 2013 Jun 12.
B-cell activating factor (BAFF), a proliferation-inducing ligand (APRIL) and apoptosis inducing ligand (TRAIL) are members of the tumour necrosis factor (TNF) family. They are the main survival factors for immature, naive and activated B cells. We have analysed BAFF, APRIL and TRAIL serum concentrations in 52 patients with newly diagnosed IgG multiple myeloma and 20 healthy volunteers. The values were significantly higher in the studied patients and advanced diseases, decreasing after chemotherapy, compared to the control group. It was established that BAFF as APRIL (but not TRAIL) correlated with adverse prognostic factors such as IL-6 and lactate dehydrogenase. Furthermore, higher concentrations of APRIL and BAFF (but not TRAIL) predicted a shorter progression free survival, suggesting thereby an important prognostic marker and a possible therapeutic target in myeloma.
B 细胞激活因子 (BAFF)、增殖诱导配体 (APRIL) 和凋亡诱导配体 (TRAIL) 是肿瘤坏死因子 (TNF) 家族的成员。它们是不成熟、幼稚和活化 B 细胞的主要存活因子。我们分析了 52 例新诊断 IgG 多发性骨髓瘤患者和 20 名健康志愿者的血清 BAFF、APRIL 和 TRAIL 浓度。与对照组相比，在研究患者和晚期疾病中，这些值显著更高，且在化疗后降低。研究发现，BAFF 和 APRIL（但不是 TRAIL）与不良预后因素（如白细胞介素 6 和乳酸脱氢酶）相关。此外，较高的 APRIL 和 BAFF 浓度（但不是 TRAIL）预示着无进展生存期较短，表明其是骨髓瘤的一个重要预后标志物和潜在的治疗靶点。
